Acute phase proteins, humoral and cell mediated immunity in environmentally-induced hyperthermia in man

  • J. Hietala
  • T. Nurmi
  • M. Uhari
  • A. Pakarinen
  • K. Kouvalainen
Article

Summary

The effects of repeated hyperthermia, caused by a Finnish sauna bath over 1 week, on the serum levels of some acute phase reactant proteins and on both humoral and cell-mediated immunity on twelve healthy young volunteers are presented. The mean rise in rectal temperature during each 30-min period in the bath was about 1.3‡ C. Heat exposure caused significant increases in the serum concentrations of two of the acute phase reactant proteins, α1-antitrypsin (from a mean value of 1.8 (0.1) to 1.9 (0.2) g·l−1,p<0.01) and transferrin (from a mean value of 36.9 (3.4) to 38.3 (4.4) Μmol·l−1,p<0.05), but no changes occurred in immunoglobulins or cell-mediated immunity. These findings suggest that environmentally induced hyperthermia can initiate the acute phase reaction associated with fever.

Key words

Hyperthermia Acute phase proteins Immunoglobulins Cell-mediated immunity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Böym A (1968) Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation. Scand J Clin Lab Invest [Suppl 97] 21: 77–89Google Scholar
  2. Bühring M, Bork-Wölwer L, Krippner H, Pirlet K (1977) Quantitative Veränderungen peripherer T-Lymphozyten unter Hyperthermie. Münch Med Wochenschr 119: 1591–1594Google Scholar
  3. Doumas BT (1975) Standards for total serum protein assays — a collaborative study. Clin Chem 21: 1159–1166PubMedGoogle Scholar
  4. Fabricius H-å, Neuman H, Engelhart R, Löhr GW (1978) Klinisch-chemische und immunologische Veränderungen bei Gesunden nach einer einstündigen 40‡ C-Ganzkörper Hyperthermie. Klin Wochenschr 56: 1049–1056CrossRefPubMedGoogle Scholar
  5. Gordon AH (1970) The effects of trauma and partial hepatectomy on the rates of synthesis of plasma proteins by the liver. In: Rothschild MA, Waldmann T (eds) Plasma protein metabolism. Academic Press, New York London, pp 351–368Google Scholar
  6. Hasan J, Karvonen MJ, Piironen P (1966) Physiological effects of extreme heat as studied in the Finnish “sauna” bath. Am J Phys Med 45: 296–314PubMedGoogle Scholar
  7. Herva E (1977) Comparison of microtitre plates with flat-bottomed and round-bottomed wells for mixed lymphocyte culture (MLC). Acta Pathol Microbiol Scand [C] 85: 90–98Google Scholar
  8. Killingsworth LM, Buffone GJ, Sonawane MB, Lungsford GC (1974) Optimizing nephelometric measurement of specific serum proteins: Evaluation of three diluents. Clin Chem 20: 1548–1552PubMedGoogle Scholar
  9. Koj A (1974) Acute phase reactants. Their synthesis, turnover, and biological significance. In: Allison AC (ed) Structure and function of plasma proteins. Plenum Publ Co Ltd, London, pp 73–131Google Scholar
  10. Mancini G, Carbonara AO, Heremans JF (1965) Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2: 235–254CrossRefPubMedGoogle Scholar
  11. Manzella JP, Roberts NJ Jr (1979) Human macrophage and lymphocyte responses to mitogen stimulation after exposure to influenza virus, ascorbic acid, and hyperthermia. J Immunol 123: 1940–1944PubMedGoogle Scholar
  12. Roberts NJ Jr, Sandberg K (1979) Hyperthermia and human leukocyte function. II. Enhanced production of and response to leukocyte migration inhibiting factor (LIF). J Immunol 122: 1990–1993PubMedGoogle Scholar
  13. Roberts NJ Jr, Steigbiegel RT (1977) Hyperthermia and human leukocyte functions: effects of response of lymphocytes to mitogen and antigen and bacterial capacity of monocytes and neutrophiles. Infect Immun 18: 673–679PubMedGoogle Scholar
  14. Smith JB, Knowlton RP, Agarwal S (1978) Human lymphocyte responses are enhanced by culture at 40‡ C. J Immunol 121: 691–694PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • J. Hietala
    • 1
  • T. Nurmi
    • 1
  • M. Uhari
    • 1
  • A. Pakarinen
    • 1
  • K. Kouvalainen
    • 1
  1. 1.The Departments of Medical Microbiology, Pediatrics and Clinical ChemistryUniversity of OuluOulu 22Finland

Personalised recommendations