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Auditory event-related potentials and reaction times during simple sensorymotor tasks in subjects with sickle cell disease and related hemoglobinopathies

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Abstract

40 subjects of both sexes assigned to five groups of 8: healthy students, homozygous sicklemics, hemoglobin SC sicklemics, sickle cell Bo thalassemics, and sickle cellB+ thalassemics were subjected to 1/simple auditory stimuli; 2/paired auditory stimuli. The subjects were asked to respond quickly, by pressing a pushbutton on detection of the simple stimulus or the unconditionnal stimulus of paired stimuli.

A subsequent increase in reaction times and a reduction in event-related potential component amplitudes were obvious in major (SS and SC) sicklemics compared to controls and sickle cell B thalassemics. Between simple and paired auditory conditions, reaction times were more increased in sicklemics than in controls.

These findings suggest that impairment of attentivenes, performance and cognitive capability in sicklemics is a function of sickle cell anemia severity.

Sommario

40 soggetti dei due sessi presi in gruppi di studenti sani e di varie categorie di malati di talassemia tipo Sickle cell sono stati sottoposti a stimoli uditivi semplici e appaiati. I soggetti sono stati invitati a rispondere premendo un tasto in relazine a uno stimolo semplice o appaiato. Si ebbe un aumento dei tempi di reazione e una riduzione dell'ampiezza dei potenziali evocati nei malati più seri comparativamente ai controlli e ai talassemici del tipo Sickle cell B. I tempi di reazione erano aumentati tra i siclemici in modo più netto che nei controlli. Questi dati fanno pensare che l'interessaménto dell'attenzione, delle performances e dell capacità cognitive nei siclemici è una espressione della severità del quadro di anemia.

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Authors and Affiliations

  1. Département de Biologie et Physiologie Animale. Laboratoire de Physiologie Animale et de Psychophysiologie, Faculté des Sciences et Techniques, 582, Abidjan 22, Côte d'Ivoire

    Hamon J. F. & Seri B.

  2. Service d'Immuno-Hématologie C.H.U. de Cocody, 582, Abidjan 22, Côte d'Ivoire

    Sangare A.

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  1. Hamon J. F.
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  2. Seri B.
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  3. Sangare A.
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Hamon, J.F., Seri, B. & Sangare, A. Auditory event-related potentials and reaction times during simple sensorymotor tasks in subjects with sickle cell disease and related hemoglobinopathies. Ital J Neuro Sci 11, 249–258 (1990). https://doi.org/10.1007/BF02333854

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