Abstract
BB-CK activity was measured in 11 patients with stroke and in 10 controls. Blood samples were taken 36 hours after the clinical stroke onset in every patient. Sera were stored at −80° and analyzed within two months. The creatine kinase isoenzymatic pattern was determined by ion-exchange column separation and gradient elution system. The mean BB-CK concentration in patients with stroke was significantly higher than in controls (p<0.01). In the group of “stroke” patients we found a correlation between severity of brain damage, as suggested by the clinical picture and CT scans, and serum values of BB-CK.
Sommario
Nel presente lavoro sono stati determinati gli isoenzimi della CK, dopo separazione su colonne a scambio ionico e dosaggio cinetico all'U.V., nel siero di 11 pazienti con ictus cerebrale e di 10 soggetti di controllo, non affetti da patologia neurologica.
I campioni di sangue venoso sono stati prelevati 36 ore dopo l'inizio della sintomatologia, sono stati congelati a −80° ed analizzati entro 2 mesi.
La concentrazione media dell'isoenzima BB della CK nei pazienti con ictus è risultata significativamente più alta che nei controlli (p<0.01). Nel gruppo di pazienti con ictus è stata trovata una correlazione fra la gravità del danno cerebrale, determinato sulla base del quadro clinico e dei reperti tomodensitometrici, e la quantità dell'isoenzima BB nel siero.
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Capocchi, G., Tassi, C., Ricci, S. et al. Creatine kinase BB activity in serum of patients with acute stroke: correlation with the severity of brain damage. Ital J Neuro Sci 8, 567–570 (1987). https://doi.org/10.1007/BF02333663
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DOI: https://doi.org/10.1007/BF02333663