Effects of various prostaglandin synthesis inhibitors on the tone of the lower oesophageal sphincter in man
The role of endogenous prostaglandins in the modulation of lower oesophageal sphincter (LES) function has been assessed by giving three structurally unrelated cyclooxygenase inhibitors and monitoring their acute effects on LES tonus and platelet thromboxane (TX) B2 production in 20 healthy volunteers.
In a double-blind, placebo-controlled, cross-over study, IV injection of soluble salts of acetylsalicylic acid and indomethacin elicited a transient increase in LES tonus of approximately 50% over baseline. A similar pattern was observed after the rectal administration of indomethacin.
In contrast, indoprofen had no measurable effect on LES tones, despite comparable inhibition of platelet cyclooxygenase activity. This may have been due to the markedly different tissue distribution of the drug.
The results suggest that endogenous prostaglandins physiologically exert an inhibitory influence on LES function.
Key wordsProstaglandins, Indoprofen, Indomethacin, Acetylsalicylic acid lower oesophageal sphincter
Unable to display preview. Download preview PDF.
- 1.Brown F, Beck B, Fletcher J, Castel D, Eastwood G (1977) Evidence suggesting prostaglandins mediate lower oesophageal sphincter (LES) incompetence associated with inflammation. Gastroenterology 72: 1033–1038Google Scholar
- 2.Castrucci G, Alimandi L, Gattavilla N, Caracciolo F, Salgarello G (1984) Esofagomanometria: aspetti metodologici ed applicazioni clinico-sperimentali. Chir Pat Sper 32: 195–213Google Scholar
- 3.Code CF, Schlegel JF (1958) The pressure profile of the gastrooesophageal sphincter in man: animproved method of detection. Proc Staff Meet Mayo Clinic 33: 406–416Google Scholar
- 5.Mc Callum RW, Ippoliti AF, Studervant RAL (1975) Effect of oral 16,16 dimetyl prostaglandin E2(PGE2) on the lower oesophageal sphincter in man. Gastroenterology 68: 949–956Google Scholar
- 6.Mayeux PR, Kadowitz PJ, Mc Namara DB (1982) Differential effects of ibuprofen, indomethacin, and meclofenamate on prostaglandin endoperoxide H2 metabolism. Molec Cell Biochem 87: 41–46Google Scholar
- 11.Rosati F, Gattavilla N, Salgarello G (1981) A simple and cheap system of perfusion for manometry. Acta Medica Rom 19: 296–300Google Scholar