Summary
The phenotypes of C3 and of Tf were determined in 818 and 576, respectively, unrelated individuals living in Liege. The gene frequencies observed are:
C3S: | 0.811 | C3F: | 0.186 | C3Var: | 0.003 |
TfC: | 0.990 | TfB: | 0.007 | TfD: | 0.003 |
The application to disputed paternity cases and to the study of twins is discussed.
Zusammenfassung
Die Bestimmung der C3 — und Tf — Phänotypen bei 818, beziehungsweise 576, Einwohnern von Liege (Belgien) ergab folgende Genfrequenzen:
C3S: | 0.811 | C3F: | 0.186 | C3Var: | 0.003 |
TfC: | 0.990 | TfB: | 0.007 | TfD: | 0.003 |
Die Verwendung dieser Gruppen in der Vaterschaftsbegutachtung und bei Zwillingenuntersuchungen wird diskutiert.
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References
Alper, C. A., Propp, R. P.: Genetic Polymorphism of the Third Component of Human Complement (C′3). J. Clin. Invest.47, 2181–2191 (1968)
Arvilommi, H.: Genetic Polymorphism of Serum C3 in Finns. Vox Sang.25, 9–27 (1973)
Azen, E. A., Smithies, O.: Genetic Polymorphism of C′3 (B1 C-globulin) in human serum. Science162, 905–907 (1968)
Bronnestam, R., Beckman, L., Cedergren, B.: Genetic Polymorphism of the Complement Component C3 in Swedish Lapps. Human Hered.21, 267–271 (1971)
Dissing, J., Sorensen, H.: Studies on C′3 Polymorphism in Denmark. Human Hered.21 272–277 (1971)
Goedde, H. W., Benkmann, H. G., Agarwal, D. P., Hirth, L.: Further Investigation on the Inherited Polymorphism of the Third Component of Complement (B1 C/B1 A-globulin). Human Hered.22, 488–495 (1972)
Kuhnl, P., Spielmann, W.: Untersuchungen zum C3-Polymorphismus (B1 C-globulin) Genfrequenzen und Familienuntersuchungen an hessischen Blutspendern und Bantupopulation Heumangenetik15, 7–13 (1972)
Mauff, G., Potrafki, B. G., Freis, H., Pulverer, G.: Vergleichende Untersuchungen zum Polymorphismus des Posttransferrins (Pt) und der dritten Komponente des Humankomplements (C3). Humangenetik21, 75–80 (1974)
Pflugshaupt, R., Scherz, R., Steinegger, L., Butler, R.: The Frenquency of the Polymorphisms of C3 in the Swiss Population and some remarks on the identification of rare phenotypes. Protides of the Biological Fluids. 22nd Colloq. 1975
Rittner, C., Rittner, B.: Report 1973/1974 of the Reference Laboratory for the Polymorphism of the Third Component (C3) Vox Sang.27, 464–472 (1974)
Smithies, O.: Variations in human serum B-globulins. Nature (Lond.)180, 1482 (1957)
Teisberg: High Voltage Agarose Gel Electrophoresis in the Study of C3 Polymorphism. Vox. Sang.19, 47–56 (1970)
Teisberg, P.: The Distribution of C3 Types in Norway. Human Hered.21, 154–161 (1971)
Teisberg, P.: C3 Types of Norvegian Lapps. Human Hered.21, 162–167 (1971)
Wieme, R. J., Demeulenaere, L.: Genetically determined electrophoretic variant of the human complement component C′3. Nature (Lond.)214, 142 (1967)
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Hoste, B., Brocteur, J., Suys, J. et al. Polymorphism of the third component (C3) of complement and of transferrin (Tf) in Belgium. Z Rechtsmed 80, 55–59 (1977). https://doi.org/10.1007/BF02332348
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DOI: https://doi.org/10.1007/BF02332348