Abstract
Female Wistar rats treated orally with a single dose (100μg/kg) of TCDD showed a biphasic decline in body weight with a cessation of food and water consumption and urine production. The first phase started immediately after dosing and lasted 7 to 10 days. There was a cessation of food and water consumption with a loss of 15 to 30% of their body weight. During the next 4 to 6 days, the rats ate and drank and regained 10 to 15% of their initial body weight. This was followed by the second phase in which food and water consumption decreased and there was another loss of body weight. Daily administration of water, electrolyte solution, or a balanced liquid diet did not alter or reverse the pattern of weight loss. Mitochondria from TCDD-treated rats were assayed and no effects were found on oxidative phosphorylation or ADP∶O ratios.
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Courtney, K.D., Putnam, J.P. & Andrews, J.E. Metabolic studies with TCDD (dioxin) treated rats. Arch. Environ. Contam. Toxicol. 7, 385–396 (1978). https://doi.org/10.1007/BF02332066
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DOI: https://doi.org/10.1007/BF02332066