Abstract
A series of experiments was conducted with chickens contaminated with dieldrin-14C to find ways of accelerating the elimination of dieldrin from their bodies. The results of these experiments indicated that charcoal, imbiber beads, and the anion exchange resins, Dowex XFS-4022 and Dowex SBR-C1, would not be useful agents for increasing the amount of dieldrin eliminatedvia feces (droppings) of chickens. Further, imbiber beads coalesced in the gizzard of the chickens and reduced their appetites. The anion exchange resin, cholestyramine, might be useful as a gastrointestinal absorbant for increasing dieldrin elimination in chickens because it increased carbon-14 elimination in droppings, but its effect on carbon-14 residues in carcasses was not clear. We elected not to investigate this compound further. Probucol, investigated because it might alter gastrointestinal absorption or blood physiology that would affect dieldrin elimination, did not increase dieldrin elimination. Severe starvation was the only method investigated that clearly was useful for increasing dieldrin elimination because it increased carbon-14 elimination in droppings and reduced carbon-14 residues in carcasses.
Similar content being viewed by others
References
Davison, K. L.: Dieldrin accumulation in tissues of the sheep. J. Agr. Food Chem.18, 1156 (1970).
Davison, K. L., and J. L. Sell: Dieldrin-14C elimination from turkeys. Arch. Environ. Contam. Toxicol.7. Accepted for publication (1978).
Davison, K. L., J. L. Sell, and R. J. Rose: Dieldrin poisoning of chickens during severe dietary restriction. Bull. Environ. Contam. Toxicol.5, 493 (1971).
Dobson, R. C., and E. R. Baugh: Dieldrin residue removal from the fat of swine. Bull. Environ. Contam. Toxicol.16, 567 (1976).
Engebretson, K. A., and K. L. Davison: Dieldrin accumulation and excretion by rats fed phenobarbital and carbon. Bull. Environ. Contam. Toxicol.6, 391 (1971).
Feil, V. J., R. D. Hedde, R. G. Zaylskie, and C. H. Zachrison: Dieldrin-14C metabolism in sheep: Identification oftrans-6,7-dihydroxydihydroaldrin and 9-(syn-epoxy)hydroxy-1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,-4endo-5,8-exo-dimethanonaphthalene. J. Agr. Food Chem.18, 120 (1970).
Hedde, R. D., K. L. Davison, and J. D. Robbins: Dieldrin-14C metabolism in sheep: Distribution and isolation of urinary metabolites. J. Agr. Food Chem.18, 116 (1970).
Sell, J. L., K. L. Davison, and D. W. Bristol: Depletion of dieldrin from turkeys. Poultry Sci.56, 2045 (1977).
Steinberg, D.: Chemotherapeutic approaches to treatment of hyperlipoproteinemia: Retrospect and prospect. 170th Amer. Chem. Soc. National Meeting, Chicago, 1975 (Cited in Chem. and Eng. News, p. 20, Sept. 15, 1975).
Wilson, K. A., and R. W. Cook: Metabolism of xenobiotics in ruminants. Use of acivated carbon as an antidote in ruminants. J. Agr. Food Chem.18, 437 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Davison, K.L., Sell, J.L. Dieldrin-14C elimination from chickens. Arch. Environ. Contam. Toxicol. 7, 369–377 (1978). https://doi.org/10.1007/BF02332064
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02332064