Clinical Rheumatology

, Volume 6, Issue 4, pp 597–599 | Cite as

Intravertebral vacuum phenomenon in multiple myeloma

  • F. Gagnerie
  • B. Taillan
  • L. Euller-Ziegler
  • G. Ziegler
Case Report


Authors report one case of intravertebral vacuum phenomenon associated with a multiple myeloma. Initially, there occurred a collapse and a lysis of the L4 vertebral body. Two months later, after chemotherapy and cobalt-therapy, X-ray examination showed a vacuum cleft phenomenon within the body of L4 and a backward displacement of the L4 posterior wall. At the same time the patient complained of a cruralgia. Recovery occurred after decompression surgery. Histologic sampling of the L4 vertebral body revealed bone necrosis without any abnormal plasmocytosis. Authors draw attention to the neurological complications occurring in the course of the vertebral necrosis and to the fact that, even in case of multiple myeloma, the occurrence of a transverse vacuum cleft may result from osteonecrosis.

Key words

Multiple Myeloma Osteonecrosis Spine Radiotherapy Vacuum Phenomenon 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Maldague, B.E., Noel, H.M., Malghem, J.J. The intravertebral vacuum cleft: a sign of ischemic vertebral collapse. Radiology 1978, 129, 23–29.PubMedGoogle Scholar
  2. 2.
    Ficat, P., Arlet, J. In: Ischémie et nécrose osseuse, Editor: Masson, Paris, 1977, 101‐108.Google Scholar
  3. 3.
    Feldmann, J.-L., Menkes, C.-J., Amor, B., Chevrot, A., Delbarre, F. L'ostéonécrose vertébrale de l'adulte. A propos de 4 cas. Rev Rhum 1981, 48, 773–780.PubMedGoogle Scholar
  4. 4.
    Gagnerie, F., Taillan, B., Commandre, F.A., Grimaud, A., Bonnard, J.-M., Grisot, C., Euller-Ziegler, L., Ziegler, G. Phénomène du vide intravertébral. A propos de sept observations. Méd Hyg 1985, 43, 1009–1018.Google Scholar
  5. 5.
    Queinnec, J.-Y., Bray de, J.-M., Audran, M., Renier, J.-C. Ostéonécrose vertébrale: à propos de 3 cas dont 1 compliqué d'une compression médullaire et 2 associés à une autre localisation nécrotique. Rev Rhum 1985, 52, 1–5.PubMedGoogle Scholar
  6. 6.
    Larde, D., Mathieu, D., Frija, J., Laston, A., Vasile, M. Spinal vacuum phenomenon: CT diagnosis and significance. J Comput Assist Tomogr 1982, 6, 671–676.PubMedGoogle Scholar
  7. 7.
    Resnick, D., Niwagana, G., Guerra, J., Vint, V., Usselman, H.: Spinal vacuum phenomenon. Anatomical study and review. Radiology 1981, 139, 341–348.PubMedGoogle Scholar
  8. 8.
    Wendling, D., Cassou, M., Guidet, M. L'image de clareté gazeuse intravertébrale. A propos de 7 nouvelles observations. Rev Rhum 1983, 50, 607–612.PubMedGoogle Scholar
  9. 9.
    Kumpan, W., Salomonowitz, E., Seidl, G., Wittich, G.E. The intravertebral vacuum phenomenon. Skel. Radiol 1986, 15, 444–447.Google Scholar

Copyright information

© Acta Medica Belgica 1987

Authors and Affiliations

  • F. Gagnerie
    • 1
  • B. Taillan
    • 1
  • L. Euller-Ziegler
    • 1
  • G. Ziegler
    • 1
  1. 1.Department of RheumatologyHôpital de l'ArchetNice CedexFrance

Personalised recommendations