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Annals of Vascular Surgery

, Volume 5, Issue 3, pp 229–233 | Cite as

The role of inflammation in nonspecific abdominal aortic aneurysm disease

  • Colleen M. Brophy
  • Jeffrey M. Reilly
  • G. J. Walker Smith
  • M. David Tilson
Article

Abstract

The predominant pathologic feature of abdominal aortic aneurysm is elastin destruction, and elastin destruction may be mediated by inflammation. In this investigation serial sections of abdominal aortic aneurysm specimens were selectively stained to study the relationship between inflammation and elastin degradation. In addition, soluble aortic extracts were examined for the presence of immunoglobulins. An inflammatory infiltrate was present in 8 of 10 of the abdominal aortic aneurysm specimens examined. The infiltrate was mononuclear, commonly located at the junction of the media and adventitia; it did not codistribute with loss of elastin. The presence of an inflammatory component in abdominal aortic aneurysm was associated with a large amount of immunoglobulin in soluble extracts from aneurysmal tissue compared to atherosclerotic and normal control extracts. This study further characterizes the microscopic pathology of abdominal aortic aneurysm and describes the presence of immunoglobulin in soluble tissue extracts. In addition, the possible role of inflammation in abdominal aortic aneurysm as it relates to protease expression is detailed.

Abdominal aortic aneurysm immunoglobulins inflammatory disease 

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Copyright information

© Annals of Vascular Surgery Inc. 1991

Authors and Affiliations

  • Colleen M. Brophy
    • 1
  • Jeffrey M. Reilly
    • 2
  • G. J. Walker Smith
    • 3
  • M. David Tilson
    • 4
  1. 1.Department of SurgeryNew England Deaconess Hospital, Harvard Surgical ServiceBoston
  2. 2.Department of SurgeryYale UniversityNew Haven
  3. 3.Department of PathologyYale UniversityNew Haven
  4. 4.Department of SurgeryRoosevelt/St. Luke's HospitalNew York

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