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Pediatric Cardiology

, Volume 7, Issue 2, pp 61–65 | Cite as

Prostaglandin levels: Predictors of indomethacin responsiveness

  • Cathy Hammerman
  • William Zaia
  • Stuart Berger
  • Elene Strates
  • Abdul Aldousany
Original Articles

Summary

Pretreatment plasma dilator prostaglandin levels were measured in 16 premature infants with patent ductus arteriosus in an attempt to correlate abnormally elevated levels with clinical responsiveness to indomethacin therapy. Nine of the 16 infants responded well to indomethacin, with complete disappearance of their murmurs by 48 h. Eight of these nine infants had elevated baseline 6 keto PGF1α levels (>500 pg/ml).

In contrast, seven of the 16 infants did not respond to indomethacin, and six of these had 6 keto PGF1α within the normal range (<500 pg/ml). PGE2 levels varied in the same general direction, but lacked the specificity and sensitivity of the 6 keto PGF1α levels. Thus, 6 keto PGF1α levels seem to correlate with, and may eventually be helpful in predicting, clinical indomethacin responsiveness in the premature neonate with patency of the ductus arteriosus.

Key words

Patent ductus arteriosus 6 keto prostaglandin F1α Prostaglandin E2 Indomethacin 

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Copyright information

© Springer-Verlag New York Inc 1986

Authors and Affiliations

  • Cathy Hammerman
    • 1
  • William Zaia
    • 1
  • Stuart Berger
    • 1
  • Elene Strates
    • 1
  • Abdul Aldousany
    • 1
  1. 1.Department of PediatricsUniversity of ChicagoChicagoUSA

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