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Electrodialytic sample treatment coupled on-line with high-performance liquid chromatography

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Summary

An electrodialytic sample treatment method coupled on-line with high-performance liquid chromatography (EDIST-HPLC) is discussed in this paper. The performance of EDIST as a function of the donor-phase (sample solution) flow rate, the voltage applied over the electrodialysis block, and the time of dialysis has been studied using the basic drug ephedrine as a model compound. Enrichment of the analyte by a factor of 10–20 was possible. The determination of human plasma spiked with ephedrine is briefly discussed.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Free University, de Boelelaan 1083, NL-1081 HV, Amsterdam, The Netherlands

    A. J. J. Debets, K. -P. Hupe & U. A. Th. Brinkman

  2. Laboratory for Analytical Chemistry, University of Amsterdam, Nieuwe Achtergracht 166, NL-1018 WV, Amsterdam, The Netherlands

    W. Th. Kok

Authors
  1. A. J. J. Debets
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  2. W. Th. Kok
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  3. K. -P. Hupe
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  4. U. A. Th. Brinkman
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Debets, A.J.J., Kok, W.T., Hupe, K.P. et al. Electrodialytic sample treatment coupled on-line with high-performance liquid chromatography. Chromatographia 30, 361–366 (1990). https://doi.org/10.1007/BF02328498

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  • DOI: https://doi.org/10.1007/BF02328498

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