Summary
Very low concentrations (down to 0.2 ng/mL) of an antispasmodic drug (Eperison) can be extracted from human plasma and analyzed by GC/MS. For sample preparation and preconcentration, solid phase extraction (SPE) has been employed. A double focussing mass spectrometer was interfaced with a capillary GC column for the GC/MS analysis. The gas chromatograph was equipped with an on-column injector to avoid thermal decomposition.
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Cappiello, A., Mangani, F., Palma, P. et al. Sub PPB level determination of eperison in human plasma by GC/MS. Chromatographia 30, 357–360 (1990). https://doi.org/10.1007/BF02328497
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DOI: https://doi.org/10.1007/BF02328497