Zusammenfassung
Das histologische Bild hypothalamischer Laesionen bei jungen Ratten zeigt sieben Tage nach dem stereotaktischen Eingriff einen dilatierten dritten Ventrikel und eine stark reduzierte Nervenmasse im Raum zwischen der Ventrikelwand und der medialen Grenze der Laesion. Vergleichbare Veränderungen sind ein oder drei Tage nach dem sterotaktischen Eingriff noch nicht zu sehen. Die Veränderungen beruhen möglicherweise auf einer sekundären Degeneration, die durch Kreislaufstörungen bedingt ist. Es wird die Frage aufgeworfen, ob die Wirkungen von elektrolytischen Laesionen im Nucleus ventromedialis nicht zum Teil auch durch die indirekte Beteiligung der perivasculären Zone mit verursacht sein könnten.
Summary
Sections from weanling rats sacrificed seven days after receiving small electrolytic lesions in the ventromedial hypothalamus show extensive ventricular dilatation and diminution of the hypothalamic tissue between the wall of the third ventricle and the medial border of the lesion. No comparable changes are evident one to three days after the placement of such lesions. It is suggested that the delayed dissolution of periventricular tissue is due to circulatory impairment elicited by the electrolytic lesion. The question is raised whether the effects of lesions in the ventromedial nucleus could not be due in part at least to such indirect involvement of the periventricular zone.
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This investigation was supported by U.S.P.H.S. Grant HD 03331, N.I.H.
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Bernardis, L.L. Delayed ventricular changes in the hypothalamus of the weanling rat following electrolytic lesions of the ventromedial nucleus. J. Neuro-Viscer. Relat 32, 347–354 (1972). https://doi.org/10.1007/BF02327929
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DOI: https://doi.org/10.1007/BF02327929