Skip to main content
SpringerLink
Log in

Effect of acetylcholine acetyl-hydrolase (E.C. 3.1.1.7) inhibition on the accumulation of pp' DDT in various brain regions of rats

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

The concentration of pp' DDT given intraperitoneally in rats was determined in different brain regions. Maximum accumulation of pp' DDT was found in the corpus striatum, followed by cerebellum and cerebral cortex in that order; following pretreatment with paraoxon the concentrations of pp' DDT were increased in all brain regions studied.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. K.A. McCully, D.C. Villeneuve, W.P. McKinley, W.E.J. Phillips and M. Hidiroglou, J. Ass. off. agric. Chem.49, 966 (1966).

    CAS  Google Scholar 

  2. W.J. Hayes, Jr, in: DDT, the insecticide dichlorodiphenyl trichloroethane and its significance, vol.2, p.100. Birkhäuser, Basel 1959.

    Book  Google Scholar 

  3. W.E. Dale, T.B. Gaines, W.J. Hayes, Jr, and G.W. Pearce, Science142, 1474 (1963).

    Article  CAS  PubMed  Google Scholar 

  4. D.E. Woolley and A.L. Runnells, Toxic. appl. Pharmac.11, 389 (1967).

    Article  Google Scholar 

  5. W.D. Black and D.J. Ecobichon, Can. J. Physiol. Pharmac.49, 45 (1971).

    Article  CAS  Google Scholar 

  6. A. Sattin, J. Neurochem.13, 515 (1966).

    Article  CAS  PubMed  Google Scholar 

  7. A. Carlsson, Pharmac. Rev.11, 490 (1959).

    CAS  Google Scholar 

  8. J.H. Quastel, in: Neurochemistry, p.431. Ch.C. Thomas, Springfield, 1962.

    Google Scholar 

  9. M.E. Greig and W.C. Holland, Science110, 237 (1949).

    Article  CAS  PubMed  Google Scholar 

  10. M.E. Greig and J.C. Mayberry, J. Pharmac.102, 1 (1951).

    CAS  Google Scholar 

  11. J. Glowinski and L.L. Iverson, J. Neurochem.13, 655 (1966).

    Article  CAS  PubMed  Google Scholar 

  12. D.F. Maunder, M.J.H. Egan, E.W. Godly, F.W. Hammond, J. Raburn and J. Thompson, Analyst89, 168 (1964).

    Article  CAS  Google Scholar 

  13. G.L. Ellman, K.D. Courtney, V. Andre, Jr, and R.M. Featherstone, Biochem. Pharmac.7, 88 (1961).

    Article  CAS  Google Scholar 

  14. G.I. Klingman, J.D. Klingman and A. Poliszczuk, J. Neurochem.15, 1121 (1968).

    Article  CAS  PubMed  Google Scholar 

  15. F. Hobbiger, in: Recent Advances in Pharmacology, 4th edn, p.281. J & A. Churchill, London 1968.

    Google Scholar 

  16. G.J. Malettaland, P.S. Timiras, J. Neurochem.13, 75 (1966).

    Article  Google Scholar 

  17. M.A. Matin, Eur. J. Pharmac.29, 168 (1974).

    Article  CAS  Google Scholar 

  18. V.H. Freed, M.A. Matin, S.C. Fang and P.P. Kar, Eur. J. Pharmac.35, 229 (1976).

    Article  CAS  Google Scholar 

  19. B. Holmstedt, Pharmac. Rev.11, 567 (1959).

    CAS  Google Scholar 

  20. J.D. Connor, G.V. Rossi and W.W. Baker, J. Pharmac.155, 545 (1967).

    CAS  Google Scholar 

  21. G.M. Evertt, L.E. Blockus and J.M. Shepperd, Science124, 79 (1956).

    Article  Google Scholar 

  22. N.E. Anden, A. Dahlstrom, K. Fuxe and K. Larsson, Acta pharmac.24, 263 (1966).

    Article  CAS  Google Scholar 

  23. A.H. Friedman and G.M. Everett, in: Advances in Pharmacology, vol. 3, p. 83. Academic Press, New York 1964.

    Book  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Industrial Toxicology Research Centre, Post Box 80, Lucknow, U.P., India

    M. A. Matin & R. Agarwal

Authors
  1. M. A. Matin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Agarwal
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

pp' DDT (1,1,1-trichloro-2,2-bis(4′-chlorophenyl ethane), used in the above studies was generously supplied by Montrose Chemical Corporation of California, USA.

The authors are grateful to Mr M.Z. Hasan for analysis of the samples and to Sandoz, Basel, Switzerland for the gift of paraoxon.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matin, M.A., Agarwal, R. Effect of acetylcholine acetyl-hydrolase (E.C. 3.1.1.7) inhibition on the accumulation of pp' DDT in various brain regions of rats. Experientia 38, 607–608 (1982). https://doi.org/10.1007/BF02327076

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02327076

Keywords

Search

Navigation