Summary
A study was made of the effect of 6 commonly used gastrointestinal preparations on the absorption of propranolol using an in vitro experimental model. The constituents examined were activated dimethicone, aluminium hydroxide gel, bismuth carbonate, kaolin, magnesium carbonate, and magnesium trisilicate. A slight decreased propranolol absorption was given by kaolin (−13.0%), the other components showed smaller effects ranging from −6.8% to +6.6%. None of the results were statistically significantly different from control absorption values.
Similar content being viewed by others
Literatur
J.A. Romankiewicz, Primary Care3, 537 (1976).
S.A.H. Khalil, J. Pharm. Pharmac.26, 961 (1974).
W.J.F. VanderVijgh, J.H. Fast and J.E. Lunde, Drug Intell. clin. Pharm.10, 680 (1976).
D.D. Brown and R.P. Juhl, N. Engl. J. Med.295, 1034 (1976).
J.C. McElnay, D.W.G. Harron, P.F. D'Arcy and M.R.G. Eagle, Experientia35, 94 (1979).
V.K. Kulshrestha, M. Thomas, J. Wadsworth and A. Richens, Br. J. clin. Pharmac.6, 177 (1978).
J.C. McElnay, D.W.G. Harron, P.F. D'Arcy and P.S. Collier, Experientia35, 1359 (1979).
J.C. McElnay, H.A. Mukhtar, P.F. D'Arcy and D.J. Temple, unpublished observations (1980).
J.H. Dobbs, V.A. Skoutakis, S.R. Acchiardo and B.R. Dobbs, Curr. ther. Res.21, 887 (1976).
P.F. D'Arcy, H.A. Muhyiddin and J.C. McElnay, J. Pharm. Pharmac.28, suppl. 33P (1976).
P.J. Neuvonen, G. Gothoni, L. Hackinan and K. Björbsten, Br. med. J.4, 532 (1970).
A.T. Chowhan and A.A. Amaro, J. Pharm. Sci.66, 1249 (1977).
Author information
Authors and Affiliations
Additional information
Acknowledgment. We are grateful to I.C.I. Ltd, Macclesfield, England, for the gift of propranolol hydrochloride and to Galen Ltd, Craigavon, Northern Ireland, for the gift of dimethicone.
Rights and permissions
About this article
Cite this article
McElnay, J.C., D'Arcy, P.F. & Leonard, J.K. The effect of activated dimethicone, other antacid constituents, and kaolin on the absorption of propranolol. Experientia 38, 605–607 (1982). https://doi.org/10.1007/BF02327075
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02327075