Summary
Topical application of phenobarbital to mice produces an increase in cutaneous microsomal proteins and apparently also of cytochrome P450, but results in a kinetically noncompetitive inhibition of p-nitrophenethole O-dealkylase activity in preparations of 10,000×g supernatant from skin.
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Pannatier, A., Testa, B. & Etter, J.C. Effect of topically applied phenobarbital on O-dealkylase activity in mouse skin. Experientia 38, 604–605 (1982). https://doi.org/10.1007/BF02327074
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DOI: https://doi.org/10.1007/BF02327074