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Ergot alkaloids and phosphodiesterase; ‘in vitro’ activities in several rat brain areas

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Summary

The ‘in vitro’ activity of ergotamine, dihydroergocristine, dihydroergocornine and dihydroergocryptine on the phosphodiesterase system at low and high Km in several rat brain areas was examined. These drugs were found to exert an inhibitory effect in all the areas examined with regard to both systems, and particularly on low substrate concentration phosphodiesterases.

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Literatur

  1. L.L. Iversen, Science1888, 1084 (1975).

    Article  Google Scholar 

  2. F.E. Bloom, Rev. Physiol. Biochem. Pharmac.74, 1 (1975).

    CAS  Google Scholar 

  3. J.W. Daly, in: Handbook of Psychopharmacology, p. 47. Eds L.L. Iversen, S.D. Iversen and S.H. Snyder, Plenum Press, New York 1975.

    Google Scholar 

  4. W.J. Thompson and M.M. Appleman, Biochemistry10, 311 (1971).

    Article  CAS  PubMed  Google Scholar 

  5. J. Glowinski and L.L. Iversen, J. Neurochem.13, 655 (1966).

    Article  CAS  PubMed  Google Scholar 

  6. P.S. Schönhöfer, J.F. Skidmore, M.R. Bourne and G. Krishna, Pharmacology7, 65 (1972).

    Article  PubMed  Google Scholar 

  7. G. Pagnini, F. Camanni, A. Crispino and P. Portaleone, J. Pharm. Pharmac.30, 92 (1978).

    Article  CAS  Google Scholar 

  8. D.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randall, J. biol. Chem.193, 265 (1951).

    Article  CAS  PubMed  Google Scholar 

  9. A. Enz, P. Iwangoff and A. Chappuis, Gerontology24, suppl 1, 115 (1978).

    Article  CAS  PubMed  Google Scholar 

  10. H. Corrodi, K. Fuxe, T. Hökfelt, P. Lidbrink and U. Ugerstedt, J. Pharm. Pharmac.25, 409 (1973).

    Article  CAS  Google Scholar 

  11. E. Flückiger and E. Del Pozo, in: Ergot Alkaloids and Related Compounds, p. 615. Eds B. Berde and H.O. Schild, Springer, Berlin 1978.

    Chapter  Google Scholar 

  12. P. Iwangoff, A. Enz and A. Chappuis, Int. Res. Comm. Syst. med. Sci.3, 403 (1975).

    CAS  Google Scholar 

  13. D.M. Loew, E.B. Van Deusen and W. Meier-Ruge, in: Ergot Alkaloids and Related Compounds, p. 421. Eds B. Berde and H.O. Schild, Springer, Berlin 1978.

    Chapter  Google Scholar 

  14. L. Saiani, M. Trabucchí, G.C. Tonon and P.F. Spano, Neurosci. Lett.14, 31 (1979).

    Article  CAS  PubMed  Google Scholar 

  15. J.W. Kebabian, Adv. cyclic nucl. Res.8, 421 (1977).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmacology, University of Turin, Corso Raffaello 30, I-10125, Turin, Italy

    P. Venutti, C. Ferretti & P. Portaleone

Authors
  1. P. Venutti
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  2. C. Ferretti
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  3. P. Portaleone
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Additional information

Acknowledgments. Ergot alkaloids were a generous gift of Poli Industria Chimica, Milan.

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Venutti, P., Ferretti, C. & Portaleone, P. Ergot alkaloids and phosphodiesterase; ‘in vitro’ activities in several rat brain areas. Experientia 38, 601–603 (1982). https://doi.org/10.1007/BF02327072

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