Skip to main content
SpringerLink
Log in

Effect of des-Tyr1-γ-endorphin on serotonin metabolism in rat brain regions

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Intracerebroventicular (i.c.v.) administration of des-Tyr1-γ-endorphin (0.1 and 1.0 μg) caused a decrease of the serotonin (5-HT) concentration of the hippocampus. The concentration of 5-HIAA and the pargyline-induced alterations in 5-HT and 5-HIAA were not affected. No effects were noticed in other brain regions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. G.R. Van Loon and E.B. De Souza, Life Sci.23, 971 (1978).

    Article  PubMed  Google Scholar 

  2. J.A. Garcia-Sevilla, L. Ahtee, T. Magnusson and A. Carlsson, J. Pharm. Pharmac.30, 613 (1978).

    Article  CAS  Google Scholar 

  3. D.A. Brase, Adv. Biochem. Psychopharmac.20, 409 (1979).

    CAS  Google Scholar 

  4. D. De Wied, G.L. Kovács, B. Bohus, J.M. Van Ree and H.M. Greven, Eur. J. Pharmac.49, 427 (1978).

    Article  Google Scholar 

  5. W.M.A. Verhoeven, H.M. Van Praag, J.M. Van Ree and D. De Wied, Archs gen. Psychiat.36, 294 (1979).

    Article  CAS  Google Scholar 

  6. J.M. Van Ree, D. De Wied, W.M.A. Verhoeven and H.M. Van Praag, Lancet2, 1363 (1980).

    PubMed  Google Scholar 

  7. J.E. Leysen, C.J.E. Niemegeers, J.P. Tollenaere and P.M. Laduron, Nature272, 168 (1978).

    Article  CAS  PubMed  Google Scholar 

  8. W. H. Gispen, P. Schotman and E.R. De Kloet, Neuroendocrinology9, 285 (1972).

    Article  CAS  PubMed  Google Scholar 

  9. G. Curzon and A.R. Green, Br. J. Pharmac.39, 653 (1970).

    Article  CAS  Google Scholar 

  10. D.H.G. Versteeg, E.R. De Kloet and D. De Wied, Brain Res.179, 85 (1979).

    Article  CAS  PubMed  Google Scholar 

  11. J.M. Van Ree, B. Bohus and D. De Wied, in: Endogenous and exogenous opiate agonists and antagonists, p. 459, Ed. E. Leong Way. Pergamon Press, New York 1980.

    Google Scholar 

  12. J.M. Van Ree, A. Witter and J.E. Leysen, Eur. J. Pharmac.52, 411 (1978).

    Article  Google Scholar 

  13. N.W. Pedigo, N.C. Ling, T.D. Reisine and H.I. Yamamura, Life Sci.24, 1645 (1979).

    Article  CAS  PubMed  Google Scholar 

  14. N.W. Pedigo, T. Schallert, D.H. Overstreet, N.C. Ling, P. Ragan, T.D. Reisine and H.I. Yamamura, Eur. J. Pharmac.60, 359 (1979).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. M. Kurachi

    Present address: Department of Neuropsychiatry, Kanazawa University School of Medicine, Kanazawa, Japan

Authors and Affiliations

  1. Department of Psychiatry and Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Vondellaan 6, NL-3521 GD, Utrecht, The Netherlands

    M. Kurachi, D. H. G. Versteeg, J. M. Van Ree, H. G. M. Westernberg & H. M. Van Praag

Authors
  1. M. Kurachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. H. G. Versteeg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. M. Van Ree
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. G. M. Westernberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. M. Van Praag
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgement. The skilful technical assistance of Ms Henny de Vos Burchart-Lodewijks and Mrs H.A. Spierenburg and J.A. Meijer is gratefully acknowledged. Des-Tyr1-γ-endorphin was a gift of Dr. H.M. Greven, Organon International B.V., Oss, The Netherlands.

To whom reprint requests should be addressed.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kurachi, M., Versteeg, D.H.G., Van Ree, J.M. et al. Effect of des-Tyr1-γ-endorphin on serotonin metabolism in rat brain regions. Experientia 38, 598–599 (1982). https://doi.org/10.1007/BF02327070

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02327070

Keywords

Search

Navigation