Experientia

, Volume 38, Issue 5, pp 556–557 | Cite as

Novel vesicular extrusions during cell spreading

  • R. Rajaraman
  • B. Westermark
  • J. Ponten
  • A. Vaheri
Specialia
  • 15 Downloads

Summary

During the late stages of cell spreading in vitro, the cells extrude a vesicular material into the medium. This phenomenon was observed in human glia and glioma cells as well as in human diploid fibroblasts MRC-5 and WI-38 cells. This extrusion of vesicular material is inhibited by cytochalasin-B and colcemid suggesting the involvement of microfilaments and microtubules and the active nature of this event. It appears that the cells may be excreting damaged surface components by a mechanism similar to patching, capping and endocytosis.

Keywords

Late Stage Glioma Cell Active Nature Cell Spreading Surface Component 

Literatur

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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • R. Rajaraman
    • 1
    • 2
    • 3
  • B. Westermark
    • 1
    • 2
    • 3
  • J. Ponten
    • 1
    • 2
    • 3
  • A. Vaheri
    • 1
    • 2
    • 3
  1. 1.Department of Medicine and MicrobiologyDalhousie UniversityHalifaxCanada
  2. 2.Department of Tumor Pathology, Wallenburg LaboratoryUniversity of UppsalaUppsala(Sweden)
  3. 3.Department of Virology, Faculty of MedicineHelsinki UniversityHelsinki(Finland)

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