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Mechanism of urea nitrogen binding by proposed oxidized starch gastrointestinal absorbents

  • Pharmacologica
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Summary

By use of14-C label it was demonstrated that apparent binding of urea N to polyaldehyde starch was probably preceeded by hydrolysis to ammonium ion. Thus direct urea binding was not the mechanism through which ingested polyaldehyde starch might increase fecal N excretion in uremic patients.

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Authors and Affiliations

  1. Drug Metabolism Section, Pharmaceutical Research and Development Department, Travenol Laboratories, 60053, Morton Grove, Illinois, USA

    I. J. Stern, R. S. Izzo, Z. Y. Jo Wang & W. E. Beschorner

Authors
  1. I. J. Stern
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  2. R. S. Izzo
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  3. Z. Y. Jo Wang
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  4. W. E. Beschorner
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Stern, I.J., Izzo, R.S., Wang, Z.Y.J. et al. Mechanism of urea nitrogen binding by proposed oxidized starch gastrointestinal absorbents. Experientia 31, 1065–1066 (1975). https://doi.org/10.1007/BF02326962

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  • DOI: https://doi.org/10.1007/BF02326962

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