Summary
Five isozymes of LDH are demonstrable in the epidermis of the ear pinnae, hind feet, trunk dorsa, and tails of adult C57BL, C57HR, and C3HB mice by polyacrylamide gel electrophoresis. LDH-5 activity predominates in electropherograms. The ratio of LDH-1 to LDH-5 is greater in the epidermis of ear pinna and trunk dorsum than in that of tail and hind foot. The region-specific patterns of epidermal LDH isozymes are not correlated with melanin pigmentation or ‘hairiness’ of the skin.
Similar content being viewed by others
Literatur
C. L. Markert andH. Ursprung, Devel. Biol.5, 363 (1962).
J. Papaconstantinou, Science156, 338 (1967).
H. B. Chase, H. Rauch andV. W. Smith, Physiol. Zool.24, 1 (1951).
B. H. Sanford, H. B. Chase, S. B. Carroll andC. T. Arsenault, Anat. Rec.152, 17 (1965).
A. A. Dietz andT. Lubrano, Analyt. Biochem.20, 246 (1967).
R. T. Schimke andD. Doyle, A. Rev. Biochem.39, 929 (1970).
M. Rosenberg, Nature New Biol.230, 12 (1971).
R. D. Glass andD. Doyle, Science176, 180 (1972).
R. E. Billingham andW. K. Silvers, J. exp. Med.125, 429 (1967).
R. E. Billingham andW. K. Silvers, J. invest. Dermat.57, 227 (1971).
C. L. Markert, Ann. N.Y. Acad. Sci.151, 14 (1968).
J. Everse, R. L. Berger andN. O. Kaplan, Science168, 1236 (1970).
C. L. Markert andH. Ursprung,Developmental Genetics (Prentice-Hall, Englewood Cliffs, New Jersey (1971).
W. E. Criss, Cancer Res.31, 1523 (1971).
T. Wuntch, R. F. Chen andE. S. Vesell, Science167, 63 (1970).
T. Wuntch, R. F. Chen andE. S. Vesell, Science169, 480 (1970).
D. A. Baeyens, J. R. Hoffert andP. O. Fromm, Comp. Biochem. Physiol.47 B, 1 (1974).
E. M. Fagereng Tvermyr, Virchows Arch., Abt. B Zellpath.2, 318 (1969).
Author information
Authors and Affiliations
Additional information
Supported by PHS Research Grant No. CA-06097 from the National Cancer Institute, United States Public Health Service.
Rights and permissions
About this article
Cite this article
Quevedo, W.C., Bienieki, T.C., Holstein, T.J. et al. Lactate dehydrogenase isozymes of mouse epidermis. Experientia 31, 1034–1036 (1975). https://doi.org/10.1007/BF02326943
Issue Date:
DOI: https://doi.org/10.1007/BF02326943