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Binding ofd-α-tocopherol to rat liver nuclear components

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Summary

Whend-α-tocopherol is administered i.v. to vitamin E dificient rats, significant amounts of this vitamin are bound to a nucleoprotein complex in hepatic nuclei, and this complex can be solubilized by high concentrations of sodium chloride (0.6M). The bound vitamin in this complex, extractable by ethanol, was found to be identical with authentic α-tocopherol by thin layer chromatography.

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Authors and Affiliations

  1. Biochemistry Research Division, Department of Medicine, Sinai Hospital of Baltimore, Inc., 21215, Baltimore, Maryland, USA

    R. N. Patnaik & P. P. Nair

Authors
  1. R. N. Patnaik
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  2. P. P. Nair
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Additional information

This investigation was supported by a research grant No. AM-02131 from the United States Public Health Service, National Institutes of Health.

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Patnaik, R.N., Nair, P.P. Binding ofd-α-tocopherol to rat liver nuclear components. Experientia 31, 1023–1024 (1975). https://doi.org/10.1007/BF02326936

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  • DOI: https://doi.org/10.1007/BF02326936

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