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Copper ion binding and enzyme inhibitory properties of the antithyroid drug methimazole

  • Specialia Chimica, Biochimica
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Summary

The antithyroid drug, methimazole (1-methyl-2-thiolimidazole), is a powerful chelator of cupric ion. This is reflected in its ability to selectively inhibit certain copper oxidases. Uricase, ascorbic oxidase and monoamine oxidase are not affected. Ceruloplasmin oxidase is slightly inhibited and tyrosinase is markedly inhibited by methimazole.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Dartmouth Medical School, 03755, Hanover, New Hampshire, USA

    D. P. Hanlon & S. Shuman

Authors
  1. D. P. Hanlon
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  2. S. Shuman
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Additional information

This work was supported in part by Dartmouth Medical School grant No. RR-05392 and USPHS grant No. GM-15549.

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Hanlon, D.P., Shuman, S. Copper ion binding and enzyme inhibitory properties of the antithyroid drug methimazole. Experientia 31, 1005–1006 (1975). https://doi.org/10.1007/BF02326924

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  • DOI: https://doi.org/10.1007/BF02326924

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