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The effects of jaundiced plasma and hypercholesterolaemic plasma on vascular sensitivity to injected noradrenaline

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Summary

Jaundiced plasma and plasma from hyperlipidaemic patients was perfused into an isolated artery or kidney preparation. The responses of the artery to doses of noradrenaline when Krebs solution was perfused were compared to the responses when the plasmas were perfused. It was found that both jaundiced and hyperlipidaemic plasmas potentiated the effects of noradrenaline on the isolated arteries and kidneys.

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Authors and Affiliations

  1. Department of Physiology, University of the Witwatersrand, Hospitalstreet, 2001, Johannesburg, South Africa

    T. A. McCalden, D. Bloom & C. Rosendorff

Authors
  1. T. A. McCalden
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  2. D. Bloom
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  3. C. Rosendorff
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Additional information

We wish to thank the Liver Unit at the South African Institute for Medical Research for all biochemical estimations and also the Lipid Clinic volunteers and staff for their assistance.

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McCalden, T.A., Bloom, D. & Rosendorff, C. The effects of jaundiced plasma and hypercholesterolaemic plasma on vascular sensitivity to injected noradrenaline. Experientia 31, 1173–1174 (1975). https://doi.org/10.1007/BF02326776

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  • DOI: https://doi.org/10.1007/BF02326776

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