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Improved HPLC methodology in occupational exposure studies on formaldehyde

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Summary

This work describes an HPLC method for the determination of formaldehyde concentration in air. Traps containing 20–40 mesh silica gel coated with 2,4-dinitrophenylhydrazine (DNPH) are used. After aspiration of air the traps are eluted with methanol. The hydrazone formed is then separated on a C18 column using a mobile phase of methanolwater (50–50 v/v). The effluent is monitored with a UV detector at 365 nm.

To calibrate and to compare this method with that of Niosh 2502 (traps coated with 2 benzylamino ethanol on Chromosorb 102), a mixing chamber that generated atmospheres of known concentration of formaldehyde was used.

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Authors and Affiliations

  1. Centro Analisi Monza (C.A.M.), SRL, Via Italia, 15, 20052, Monza, (MI), Italy

    M. Colli, A. Gironi & V. Molina

  2. Dipartimento Medicina Preventiva, Sezione Igiene, Università di Pavia, Italy

    R. Marchetti

  3. Fondazione Mondino, Università di Pavia, Italy

    G. Melzi D'Eril

  4. Istituto Superiore di Sanita', Roma, Italy

    C. Lucarelli

Authors
  1. M. Colli
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  2. A. Gironi
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  3. V. Molina
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  4. R. Marchetti
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  5. G. Melzi D'Eril
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  6. C. Lucarelli
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Colli, M., Gironi, A., Molina, V. et al. Improved HPLC methodology in occupational exposure studies on formaldehyde. Chromatographia 32, 113–115 (1991). https://doi.org/10.1007/BF02325012

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  • DOI: https://doi.org/10.1007/BF02325012

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