Summary
A rapid and convenient method for the full O-alkylation of pentaerythritol was investigated. The method involves an alkyl halide in a polar aprotic solvent, in the presence of sodium hydroxide. The optimal reaction conditions were studied for methyl iodide, ethyl iodide and bromide, n-propyl bromide and n-butyl bromide. Methyl and propyl derivatives were quantitatively obtained in a short reaction time. The method was applied for the gas chromatographic—mass spectrometric analysis of a commerical pentaerythritol sample.
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Ciucanu, I., Gabris, P. Peralkylation of pentaerythritol for gas chromatographic— mass spectrometric analysis. Chromatographia 23, 574–578 (1987). https://doi.org/10.1007/BF02324867
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DOI: https://doi.org/10.1007/BF02324867