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Indirect detection in reversed-phase liquid chromatography: Ion-pair retention models for ionic compounds on μ Bondapak phenyl

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Summary

Retention models for ionic compounds in reversed-phase ion-pair chromatographic systems have been developed on the basis of the capacity ratios of solutes and ionic mobile phase components using indirect detection. The binding to the adsorbent, μBondapak Phenyl, has been expressed by ion-pair distribution constants and tested in the retention models by non-linear regression.

All the ionic compounds followed adsorption models of the Langmuir type comprising two kinds of binding sites with widely different adsorption capacities and binding constants. The results indicate certain differences between the two sites regarding the binding of cationic and anionic components, respectively.

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Author notes

  1. L. Hackzell

    Present address: ACO Läkemedel AB, P.O. Box 3026, S-171 03, Solna, Sweden

Authors and Affiliations

  1. Dept. of Analytical Pharmaceutical Chemistry, Uppsala University Biomedical Center, P.O. Box 574, S-751 23, Uppsala, Sweden

    E. Arvidsson, L. Hackzell, G. Schill & D. Westerlund

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  1. E. Arvidsson
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  2. L. Hackzell
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  3. G. Schill
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  4. D. Westerlund
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Arvidsson, E., Hackzell, L., Schill, G. et al. Indirect detection in reversed-phase liquid chromatography: Ion-pair retention models for ionic compounds on μ Bondapak phenyl. Chromatographia 25, 430–436 (1988). https://doi.org/10.1007/BF02324787

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  • DOI: https://doi.org/10.1007/BF02324787

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