Summary
D,L-amino acids were derivatized with (+), (±)-2-butanol or N-trifluoroacetyl-L-prolyl chloride (L-TPC) and then chromatographed. Four optical isomers were separated on a Chirasil-Val capillary column. By this method, the concentration of optical impurities arising from the commercial optically active reagents can be determined. The observed abnormal elution orders of enantiomeric amino acid esters may be caused by a selective intermolecular force.
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Liu, DM. Gas chromatographic resolution of enantiomeric and diastereoisomeric amino acid esters on Chirasil-Val capillary column. Chromatographia 25, 393–396 (1988). https://doi.org/10.1007/BF02324780
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DOI: https://doi.org/10.1007/BF02324780