Summary
With the molecular hydrophobic feature represented by Van der Waals molecular volume, the-hydrophilic parameter of substituting groups in mono-substituted benzenes was determined, in order to predict the retention of substituted benzenes in RP-HPLC. Thus it is possible to predict the retention of multi-functional substituted benzenes. The agreement between the calculated and the measured retention values shows that the proposed model to deal with retention of solutes is reasonable.
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Yuqi, F., Pengling, Z. & Zhide, H. Study on the relationship between chromatographic retention behaviour and molecular structure. Chromatographia 25, 382–388 (1988). https://doi.org/10.1007/BF02324778
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DOI: https://doi.org/10.1007/BF02324778