Abstract
Escape from pre-implantation lethality by homozygousyellow embryos depends on differentiation of trophoblastic cells. The evidence presented herein suggests that progesterone stimulated differentiation of trophoblastic giant cells in some homozygousyellow blastocysts and thereby increased the percentage ofA y/Ay “escaper” embryos.
Similar content being viewed by others
References
Dickson, A. D. (1967). Induction of the trophoblast giant-cell transformation after ovariectomy in the mouse.J. Embryol. Exp. Morph. 17: 189–193.
Eaton, G. J. & M. M. Green (1962). Implantation and lethality of theyellow mouse.Genetica 33: 106–113.
Eaton, G. J. & M. M. Green (1963). Giant cell differentiation and lethality of homozygousyellow mouse embryos.Genetica 34: 155–161.
Potts, D. M. & I. R. Wilson (1967). The preimplantation conceptus of the mouse at 90 hourspost coitum.J. Anat. 102: 1–11.
Robertson, G. G. (1942). An analysis of the development of homozygousyellow mouse embryos.J. Exp. Zool. 89: 197–231.
Wolff, G. L. & A. Bartke (1966). Decreased survival of embryos inyellow (Ay/a) female mice.J. Hered. 57: 14–17.
Author information
Authors and Affiliations
Additional information
This work was supported in part by funds from research grant HDOOO36, National Institute of Child Health and Development, National Institutes of Health, U.S.A.
Rights and permissions
About this article
Cite this article
Eaton, G.J. Stimulation of trophoblastic giant cell differentiation in the homozygousYellow mouse embryo. Genetica 39, 371–378 (1968). https://doi.org/10.1007/BF02324477
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02324477