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Clinical Autonomic Research

, Volume 11, Issue 2, pp 99–108 | Cite as

Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate

  • Marcus W. Agelink
  • Rolf Malessa
  • Bruno Baumann
  • Thomas Majewski
  • Frank Akila
  • Thomas Zeit
  • Dan Ziegler
Research Article

Abstract

The authors undertook this study to determine the effects of age, gender, and heart rate (HR) on the results of cardiac autonomic function tests for measuring heart rate variability (HRV) in a large sample of healthy subjects (n=309). Conventional tests (deep breathing, maximum/minimum 30∶15 ratio), and a standardized 5-minute resting study, including spectral analysis of HR, were used. The main findings included (1) the indices of all tests, except for the ratio of the low- (LF) to high-frequency (HF) spectral power (LF/HF ratio) and HR itself, are inversely related to age in both sexes; (2) the 5-minute spectral bands (except for the LF/HF ratio), the variation coefficient, expiratory-inspiratory ratio during deep breathing, and the maximum/minimum 30∶15 ratio are independent of HR; (3) women up to the age of 55 years have a higher resting HR compared with men; (4) young and middleaged women show a significantly lower LF power and LF/HF ratio compared with age-matched men, whereas no significant gender differences are observed in the absolute HF power. The authors computed age- and gender-dependent normal values for each of the HRV indices studied here and discuss the clinical consequences arising from gender differences in HRV.

Key words

autonomic nervous system human cardiovascular regulation heart rate variability 30∶15 ratio deep breathing test 

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Copyright information

© Lippincott Williams & Wilkins 2001

Authors and Affiliations

  • Marcus W. Agelink
    • 1
  • Rolf Malessa
    • 2
  • Bruno Baumann
    • 3
  • Thomas Majewski
    • 5
  • Frank Akila
    • 4
  • Thomas Zeit
    • 1
  • Dan Ziegler
    • 4
  1. 1.Institute of Biological Psychiatry and Neuroscience at the Evangelical Clinics GelsenkirchenRuhr-University of BochumGelsenkirchenGermany
  2. 2.Department of Neurology, Hufeland Clinic WeimarUniversity of JenaJenaGermany
  3. 3.Department of PsychiatryOtto von Guericke UniversityMagdeburgGermany
  4. 4.German Diabetes Research Institute at the Heinrich-Heine UniversityDüsseldorfGermany
  5. 5.Department of Internal MedicineEvangelical ClinicsGelsenkirchenGermany

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