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On the use of sequential simplex procedure for optimization of basic parameters influencing temperature in LTPGC analysis of multicomponent samples

  • Late Papers from the 17th International Symposium on Chromatography, Vienna, Austria, September 25–30, 1988
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Summary

A procedure for the sequential simplex optimization of initial temperature (T0), hold time (t0) and rate of temperature change (r) is illustrated by applying it to the separation of a multicomponent sample by linear temperature programmed capillary gas chromatographic analysis (LTPCGC). A procedure is described which enables the correct retention times and peak areas of individual peaks in partially overlapping gaussian shaped peak pairs to be obtained. A new optimization criterion (Cp) is proposed:

$$C_p = N_r + \frac{{(t_{R,n} - t_{max} )}}{{t_{max} }}$$

where the main part is represented by a number of peaks (Nr) detected by an integrator. The secondary part relates to the duration of the analysis (tR, n).

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Radlinského 9, 812 37, Bratislava, Czechoslovakia

    J. Krupčík, D. Repka, T. Hevesi, E. Benická & J. Garaj

Authors
  1. J. Krupčík
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  2. D. Repka
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  3. T. Hevesi
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  4. E. Benická
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  5. J. Garaj
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Krupčík, J., Repka, D., Hevesi, T. et al. On the use of sequential simplex procedure for optimization of basic parameters influencing temperature in LTPGC analysis of multicomponent samples. Chromatographia 27, 367–370 (1989). https://doi.org/10.1007/BF02321285

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  • DOI: https://doi.org/10.1007/BF02321285

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