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Synthesis of mesityl-substituted 1,3,4-oxadiazoles from mesitotrichloride and aromatic and heteroaromatic acid hydrazides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

At interaction of 2,4,6-trimethylbenzotrichloride with aromatic (heteroaromatic) acid hydrazides in a mixture of 2,6-lutidine and tert-butanol the processes of alcoholysis and reductive condensation are suppressed. The corresponding 2-aryl- or 2-hetaryl-5-mesityl-1,3,4-oxadiazoles are obtained in high yields. The PMR, IR, and mass spectra of the products are studied.

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Authors
  1. L. I. Belen'kii
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  2. S. I. Luiksaar
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  3. M. M. Krayushkin
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Additional information

Dedicated to Professor Henk van der Plas on his 70th birthday.

N. D. Zelinskii Institute of Organic Chemistry, Moscow 117913, Russia

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 557–563, April, 1999.

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Belen'kii, L.I., Luiksaar, S.I. & Krayushkin, M.M. Synthesis of mesityl-substituted 1,3,4-oxadiazoles from mesitotrichloride and aromatic and heteroaromatic acid hydrazides. Chem Heterocycl Compd 35, 492–498 (1999). https://doi.org/10.1007/BF02319340

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  • DOI: https://doi.org/10.1007/BF02319340

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