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Alkylation of hetaryl methyl ketones by propargyl bromide under phase-transfer catalysis conditions

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The alkylation of aryl and hetaryl methyl ketones by propargyl bromide using the phase-transfer catalysis system KOH (s)/18-crown-6/benzene is studied. The corresponding C-trialkylated products are selectively obtained in 34–78% yields.

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Authors
  1. E. Abele
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  2. R. Abele
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  3. Yu. Popelis
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  4. I. Mazheika
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  5. E. Lukevics
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Additional information

Dedicated to Professor Henk van der Plas on his 70th birthday.

Latvian Institute of Organic Synthesis, Riga LV-1006,

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 495–497, April, 1999.

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Abele, E., Abele, R., Popelis, Y. et al. Alkylation of hetaryl methyl ketones by propargyl bromide under phase-transfer catalysis conditions. Chem Heterocycl Compd 35, 436–438 (1999). https://doi.org/10.1007/BF02319330

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  • DOI: https://doi.org/10.1007/BF02319330

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