Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats
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The effects of the cholinesterase inhibitors physostigmine and tetrahydroaminoacridine (THA) on memory and performance deficits induced by scopolamine were studied using an operant delayed non-matching to position task. No effect was seen on the performance of rats when treated with either physostigmine (0.1 mg/kg IP) or THA (1 mg/kg IP) alone. However, the performance deficits induced in the task by scopolamine (0.03 mg/kg SC) were reversed by the same doses of the cholinesterase inhibitors.
Key wordsTetrahydroaminoacridine Physostigmine Delayed non-match to sample Scopolamine Rat
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