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Psychopharmacology

, Volume 105, Issue 1, pp 134–136 | Cite as

Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats

  • T. K. Murray
  • A. J. Cross
  • A. R. Green
Rapid Communications

Abstract

The effects of the cholinesterase inhibitors physostigmine and tetrahydroaminoacridine (THA) on memory and performance deficits induced by scopolamine were studied using an operant delayed non-matching to position task. No effect was seen on the performance of rats when treated with either physostigmine (0.1 mg/kg IP) or THA (1 mg/kg IP) alone. However, the performance deficits induced in the task by scopolamine (0.03 mg/kg SC) were reversed by the same doses of the cholinesterase inhibitors.

Key words

Tetrahydroaminoacridine Physostigmine Delayed non-match to sample Scopolamine Rat 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • T. K. Murray
    • 1
  • A. J. Cross
    • 1
  • A. R. Green
    • 1
  1. 1.Astra Neuroscience Research UnitLondonUK

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