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The quantitative analysis of the diastereoisomers of salmefamol and labetalol by gas-liquid chromatography

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Summary

The separation of the diastereoisomeric racemates of salmefamol and labetalol has been investigated systematically. The O-tertiarybutyldimethylsilyl, N-trifluoroacetyl derivatives have been found to give good separation and to provide a method of quantitative analysis suitable for quality control purposes. For labetalol, prior conversion of the amide into nitrile has been found to be necessary.

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Authors and Affiliations

  1. Analytical Research Department, Allen & Hanburys Research Limited, Ware, Hertfordshire, UK

    G. Munro, J. H. Hunt & L. R. Rowe

  2. Applied Chemistry Group, School of Natural Sciences, The Hatfield Polytechnic, Hatfield, Hertfordshire, UK

    M. B. Evans

Authors
  1. G. Munro
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  2. J. H. Hunt
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  3. L. R. Rowe
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  4. M. B. Evans
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Munro, G., Hunt, J.H., Rowe, L.R. et al. The quantitative analysis of the diastereoisomers of salmefamol and labetalol by gas-liquid chromatography. Chromatographia 11, 440–446 (1978). https://doi.org/10.1007/BF02314783

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  • DOI: https://doi.org/10.1007/BF02314783

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