, Volume 23, Issue 2, pp 141–142 | Cite as

TLC resolution of enantiomeric mixtures of amino acids

  • R. Bhushan
  • I. Ali
Short Communication


Resolution of enantiomeric mixtures of DL-amino acids (Nine) using silica gel layers impregnated with (-)-bruncine is reported. The solvent system used was Butanol: Acetic acid: Chloroform (3∶1∶4). The diastereomers were formed and hydrolysed, by dilute HCl spray, on the chromatogram only and the amino acids thus resolved were located by ninhydrin spray. The cross resolution possibilities of enantiomers were also calculated.

Key Words

Thin-layer chromatography Brucine impregnated silica gel Resolution of enantiomers Amino acids 


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • R. Bhushan
    • 1
  • I. Ali
    • 1
  1. 1.Department of ChemistryUniversity of RoorkeeRoorkeeIndia

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