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Psychopharmacology

, Volume 120, Issue 3, pp 303–310 | Cite as

The discriminative stimulus effects of methamphetamine in pigeons

  • J. E. Sasaki
  • T. A. Tatham
  • J. E. Barrett
Original Investigation

Abstract

This experiment was designed to elucidate the neurotransmitter systems that mediate the discriminative stimulus effects of methamphetamine. Four pigeons were trained to peck one key following saline injections and a second key following methamphetamine injections (1.0 or 1.7 mg/kg, IM). Substitution tests revealed drug-appropriate responding following administration of the psychomotor stimulants methamphetamine, amphetamine and cocaine, the dopamine (DA) reuptake inhibitor bupropion, norepinephrine (NE) reuptake inhibitors imipramine and tomoxetine, and the serotonin (5-HT) releaser fenfluramine. Salinekey responding occurred following administration of the D1 agonist SKF-38393, the D1 antagonist SCH-23390, the α2 receptor agonist clonidine, the α1 antagonist prazosin, a nonselective β-antagonist propranolol and the selective 5-HT reuptake inhibitor fluoxetine. The D2/D3 agonist quinpirole produced drug-appropriate responding in two pigeons and partial substitution in the remaining two pigeons. The 5HT1A agonist 8-OH-DPAT produced drug-appropriate responding at higher doses (0.3–1.0 mg/kg), whereas much lower doses (0.003–0.1 mg/kg) antagonized the methamphetamine stimulus. The stimulus effects of methamphetamine were attenuated by pretreatment with prazosin, SCH-23390 and eticlopride, whereas pretreatment with propranolol and the 5-HT3 antagonist, MDL 72222, failed reliably to attenuate drug key responding. These results suggest that NE and DA reuptake inhibition and 5-HT release mediate the discriminative stimulus effects of methamphetamine as do the 5-HT1A and DA D1 and D2 receptors.

Key words

Methamphetamine Drug discrimination Key pecking Pigeons Dopamine Norepinephrine Serotonin 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • J. E. Sasaki
    • 1
  • T. A. Tatham
    • 1
  • J. E. Barrett
    • 2
  1. 1.Behavioral Pharmacology Laboratory, Department of Psychiatry, Uniformed ServicesUniversity of the Health SciencesBethesdaUSA
  2. 2.Lederle LaboratoriesCentral Nervous System ResearchPearl RiverUSA

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