Journal of Biological Physics

, Volume 5, Issue 1–2, pp 24–48 | Cite as

Discriminant analysis. 2. A new index for antitumor activity

  • Ernest M. Hodnett
  • Jafargholi Amirmoazzami
  • Gopalakrishnan Prakash


The antitumor activities of 17 nitrogen analogs of 1, 4-benzoquinone, expressed in eight different ways, were subjected to discriminant analysis. Different methods of measuring the effectiveness of antitumor agents give different results. Methods based on dose levels such as the optimum dose or the lethal dose appear to be more useful in classifying compounds as antitumor agents than methods based on the maximum antitumor effect. A new index for antitumor activity involving the maximum antitumor effect, the optimum dose, and the therapeutic index, examined by discriminant analysis with substitutive parameters as discriminatory variables, can give valuable information for the design of new antitumor drugs.


Nitrogen Polymer Statistical Physic Dose Level Antitumor Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hansch, C., and T. Fujita. 1964. J. Amer. Chem. Soc.,86, 1616; Hansch, C. 1969. Accts. Chem. Research.,2, 232.Google Scholar
  2. 2.
    Hammett, L. P. 1970. Physical Organic Chemistry, 2nd Edition, McGraw-Hill, New York, N.Y.Google Scholar
  3. 3.
    Swain, C. G., and E. C. Lupton. 1968. J. Amer. Chem. Soc.,90, 4328.CrossRefGoogle Scholar
  4. 4.
    Vogel, A. I. 1948. J. Chem. Soc., 1833.Google Scholar
  5. 5.
    Hansch, C., and J. Fukunaga. 1977. Chem. Tech.,7, 120.Google Scholar
  6. 6.
    Hansch, C., A. Leo, S. H. Unger, K. H. Kim, D. Nakaitani, and E. J. Lien. 1973. J. Med. Chem.,16, 1207.Google Scholar
  7. 7.
    BMD - Biomedical Computer Programs, Edited by W. J. Dixon, University of California Press, Berkeley, California, 1971, p. 214a.Google Scholar
  8. 8.
    Prakash G., and E. M. Hodnett, accepted for publication in J. Med. Chem.,21 (1978).Google Scholar
  9. 9.
    Hodnett, E. M., G. Prakash, and J. Amirmoazzami, J. Med. Chem.,21, 11 (1978).Google Scholar

Copyright information

© Physical Biological Sciences Ltd 1978

Authors and Affiliations

  • Ernest M. Hodnett
    • 1
  • Jafargholi Amirmoazzami
    • 1
  • Gopalakrishnan Prakash
    • 1
  1. 1.Department of ChemistryOklahoma State UniversityStillwater

Personalised recommendations