Choroidal ganglioneuroma in neurofibromatosis

  • J. J. Woog
  • D. M. Albert
  • J. Craft
  • N. Silberman
  • D. Horns
Article

Abstract

A twenty-one year old female with previously unsuspected neurofibromatosis presented for evaluation of a blind painful eye. Histopathologic examination of the enucleated specimen revealed choroidal thickening with ovoid bodies and proliferation of connective tissue with pigment-containing cells and ganglion-like cells. Electron microscopic study of the latter cell population revealed typical morphologic features of ganglion cells, including numerous electron-dense intracellular granules and an abundance of mitochondria and rough endoplasmic reticulum. These pathologic findings were interpreted as consistent with the diagnosis of choroidal ganglioneuroma occurring in the context of ocular neurofibromatosis. The literature concerning this unusual tumor is reviewed and the possible relationship of this lesion to neurofibromatosis and other disorders of neural cresent proliferation are briefly discussed.

Keywords

Endoplasmic Reticulum Connective Tissue Ganglion Cell Microscopic Study Histopathologic Examination 

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Copyright information

© Springer-Verlag GmBH & Co. KG, Berlin Heidelberg 1983

Authors and Affiliations

  • J. J. Woog
    • 1
  • D. M. Albert
    • 1
    • 2
  • J. Craft
    • 2
  • N. Silberman
    • 3
  • D. Horns
    • 4
  1. 1.Harvard Medical School, Massachusetts Eye and Ear InfirmaryMassachusetts
  2. 2.Massachusetts Eye and Ear InfirmaryBostonUSA
  3. 3.Mercy HospitalDes MoinesUSA
  4. 4.MinneapolisUSA

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