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Topographic genotyping of colorectal carcinoma: From a molecular carcinogenesis model to clinical relevance

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Abstract

Background: In recent years, as a result of refinement in molecular biology techniques, significant progress has been made in the understanding of colorectal carcinogenesis. Particular attention has been drawn to identification of genetic mutation that may predispose to colorectal carcinoma (familial syndromes) and may affect tumor behavior and prognosis (sporadic cases).

Conclusions: Our method of topographic genotyping of human colonic carcinomas has shown a correlation between K-ras-2 and p53 mutations and stage- at diagnosis as well as long-term survival. Data from other investigators in this field confirm the importance of genetic analysis of human colorectal tumors. These findings are likely to impact management by allowing a more individualized therapeutic approach.

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Authors and Affiliations

  1. From the Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence, Rhode Island

    Victor E. Pricolo MD & Kirby I. Bland MD

  2. Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.

    Sydney D. Finkelstein MD

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  1. Victor E. Pricolo MD
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Pricolo, V.E., Finkelstein, S.D. & Bland, K.I. Topographic genotyping of colorectal carcinoma: From a molecular carcinogenesis model to clinical relevance. Annals of Surgical Oncology 4, 269–278 (1997). https://doi.org/10.1007/BF02306621

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