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Abbreviations
- HG-PRT:
-
hypoxantoineguanine-phosphoribosyltransferase
- A-PRT:
-
adenine-PRT: 5NT-5′-Nucleotidase
- PNP:
-
purinenucleosidephosphorylase
- TPMT:
-
thiopurinemethyltransfcrase
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Author information
P. Szüts & Z. Havass
Present address: Dept. of Pediatrics, Albert Szent-Györgyi University Medical School, P.O.B. 471, H 6701, Szeged, Hungary
Authors and Affiliations
Istituto di Biochimica e di Enzimologia, Universita Degli Studi di Siena, Pian dei Mantellini, 44, 53100, Siena, Italia
A. B. Agostinho, F. Rosi, A. Tabucchi, F. Carlucci & M. Pizzichini
Medical Nobel Institute, Department of Biochemistry I, Karolinska Institutet, S-104 01, Stockholm, Sweden
A. Tabucchi, M. Pizzichini, M. L. Pandolfi, L. Arezzini, L. Terzuoli & R. Pagani
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Rakowiecka 36, 02-532, Warsaw, Poland
Elias S. J. Arnér & Staffan Eriksson
Institute of Genetic and Animal Breeding, Polish Academy of Sciences, Rakowiecka 36, 02-532, Warsaw, Poland
Staffan Eriksson & Anna Karlsson
Department of Oncology, Free University Hospital, PO Box 7057, 1007, MB Amsterdam, The Netherlands
J. Barankiewicz, H. Trembacz & L. Zwierzchowski
Laboratoire de biochimie, Hopital Debrousse, 29 rue soeur Bouvier, 69322, Lyon Cedex 05, France
J. Barankiewicz, H. Trembacz & L. Zwierzchowski
Laboratoire des sciences analytiques, CNRS, 43 Boulevard du 11 novembre 1918, 69100, Villeurbanne, France
Jong D. de, Huysmans F., Abreu R. De, Monnens L., Dijkman H., Liebergen F. van & Assmann K.
Department of Biophysics, Institute of Experimental Physics, University of Warsaw, 93 Zwirki i Wigury, 02-089, Warsaw, Poland
A. Bzowska, E. Kulikowska & D. Shugar
Institute of Experimental Biology, Armenian Academy of Sciences, 375044, Erevan, Armenia
A. V. Ananlev
Institute of Organic Synthesis, Latvian Academy of Sciences, 226006, Riga, Latvia
N. Ramzaeva, E. Alksins & J. A. Maurins
Purine Research Laboratories, UMDS, Guy's Hospital, London Bridge, SE1 9RT, UK
H. Trembacz & M. M. Jezewska
Dept. of Medical Chemistry, Dept. of Oncology, Vrije Universiteit, Van der Boechorststraat 7, 1081, BT Amsterdam, the Netherlands
A. M. Bergman, V. W. T. Ruiz van Haperen, G. Veerman, J. B. Vermorken & G. J. Peters
Dpts. of Nephrology, Pediatrics and Pathology, University Hospital Nijmegen and Bosch Medicentrum, the Netherlands
P. Miscetti, A. Minelli, A. Proietti, M. Moroni & I. Mezzasoma
Purine Research Laboratory, UMDS Guy's Hospital, SE1 9RT, London, UK
H. A. Simmonds & J. A. Duley
Department of Paediatrics, University Hospital, D-3400, Göttingen, Germany
F. Hanefeld
Purine Res.Lab.of UMDS, Guy's Hospital, SE1 9RT, London, UK
G. J. Peters, T. W. De Graaf & W. Van Dijk
Dept.General Chemistry, Medical Univ.of łódz, Poland
H. A. Simmonds, K. Fabianowska-Majewska, A. J. Duley, J. Greger & T. Wasiak
Dept.Biochemistry, Medical Univ. of łódz, Poland
H. A. Simmonds, K. Fabianowska-Majewska, A. J. Duley, J. Greger & T. Wasiak
Medizinische Poliklinik der Universitat München, Pettenkoferstr. 8a, 80336, München, Germany
B. S. Gathof, T. Ried, K. Zwieauer & U. Gresser
Allgem. öffentl. Krankenhaus St. Pölten, Austria
K. Zwieauer
II. Dept, of Surgery, Clin. Biochemistry, 9, Spitalg. 23, Vienna, Austria
A. Griesmacher, G. Weigel & M. M. Müller
Medizinische Poliklinik, University of Munich, Pettenkoferstr. 8a, 8000, München 2, Germany
U. Gresser, M. Gross & W. Empl
Institut de Pharmacologie et Toxicologie, Université de Lausanne, Bugnon 27, CH 1005, Lausanne, Switzerland
B. Guisan & F. Roch-Ramel
Dept. of Chemical Pathology, University of Cape Town, Observatory, 7925, Cape, South Africa
E. H. Harley & I. Baumgarten
Department of Biochemistry, Academic Medical School, Gda¯nsk, Poland
Kaletha K. & Nagel-Starczynowska G.
Department of Biochemistry 1, Medical Nobel Institute, Karolinska Institute, Box 60 400, S-104 01, Stockholm, Sweden
C. Bory, C. Chantin & J. L. Rocca
Depts. of Rheumatology and Pediatrics, University Hospital Nijmegen, PO Box 9101, 6500, HB Nijmegen, the Netherlands
L. Lambooy & R. De Abreu
Institute for Genetics of Microorganisms, 1st Dorozhny 1, 113545, Moscow, Russia
A. A. Komissarov, D. V. Romanova & V. G. Debabov
Cancer Research Center, Institute of Tumor Experimental Diagnostics and Therapy, Russian Academy of Medical Sciences, Kashirskoe st. 24, Moscow, Russia
A. M. Kozlov
Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia
V. B. Sokolov, A. Y. Aksinenko & V. I. Fetisov
Teijin Institute for Bio-medical Research, Asahigaoka 4-3-2 Hino., 191, Tokyo, Japan
Keiji Komoriya, Yoshio Osada, Masaichi Hasegawa, Shiro Kondo, Ronald C. Couch & Travis B. Griffin
White Sands Research Center, 1300 La Velle Road, 88310, Alamogordo, NM
Ronald C. Couch & Travis B. Griffin
Institut für Physiologische Chemie, Klinikum der Philipps-Universitat Marburg, Karl-von-Frisch-Str., D-35011, Marburg, Germany
G. Lakaschus, H. G. Löffler & M. Löffler
Dept. of Internal Medicine, Dept. of Hematology, Móstoles Hospital, Rio Jucar s/n 28935 Móstoles, Madrid, Spain
M. López Jiménez, M. A. Salinero, J. Sánchez Guilarte, J. Perianes Matesanz, L. Vigil Medina & J. Ruiz Galiana
Department of Biochemistry, University Medical School of Gdansk, Poland
H. A. Simmonds, M. Marlewski, R. T. Smolenski, J. Swierczynski, B. Rutkowski & M. M. Zydowo
Purine Research Laboratory, Guy's Hospital, London, UK
H. A. Simmonds, M. Marlewski, R. T. Smolenski, J. Swierczynski, B. Rutkowski & M. M. Zydowo
Dpt. Biologia Molecolare, Università di Siena, Italia
V. Micheli, M. Pescaglini, S. Sestini, G. Jacomelli, C. Magagnoli, G. Pompucci & G. Hayek
Rip. Neuropsichiatria Infantile, USL 30, Siena, Italia
G. Hayek
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Avenue Hippocrate 75, B-1200, Brussels, Belgium
M. Mimouni, F. Boptemps & G. Van den Berghe
Dpt. of Internal Medicine and Clinical Pharmacology, La Paz University Hospital, Paseo de la Castellana, 261, 28046, Madrid, Spain
M. E. Miranda, F. A. Mateos, E. Herrero, A. González & J. G. Puig
Dept. Experimental Medicine and Biochemical Science, University of Perugia, via del Giochetto, 06100, Perugia, Italy
H. A. Simmonds & W. Makarewicz
Purine Research Laboratory, Guy's Hospital, London, England
H. A. Simmonds, J. F. Moro & M. B. McBride
Paediatric Research Unit, Guy's Hospital, London, England
I. Noam & C. G. P. Mathew
Renal Unit, Guy's Hospital, London, England
J. S. Cameron & C. S. Ogg
“La Paz” university Hospital, Madrid, Spain
J. G. Puig, M. E. Miranda & F. A. Mateos
Dept. Experimental Medicine and Biochemical Science, University of Perugia, via del Giochetto, 06100, Perugia, Italy
A. Minelli, M. Moroni, I. Mezzasoma & L. Luzi
Dept. of Oncology, Free University Hospital, The Netherlands
G. J. Peters, P. Noordhuis, K. Kazemier & G. J. L. Kaspers
Dept. of Pediatrics, P.O. BOX 7057, 1007, MB Amsterdam, The Netherlands
K. Kazemier & G. J. L. Kaspers
Dept. of Medical Biochemistry and Genetics, Laboratory of Medical Biochemistry B, The Panum Institute, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark
K. Overgaard-Hansen, M. Marcussen & H. Klenow
Ospedale Civile di Pescara e Cattedra di Patologia Clinica dell' Università di Chieti, Italy
A. Pelatti, C. P. Quaratino, C. D'Amario, R. Tentarelli & A. Giacomello
Dipartimento di Biologia Molecolare, Università di Siena, Italy
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Rep. Neuropsichiatria, USL 30, Siena, Italy
G. Hayek
Institute of Biochemistry and Enzymology, University of Siena, Pian dei Mantellini 44, 53100, Siena, Italy
C. Bory, C. Chantin & J. L. Rocca
Ospedale Renzetti di Lanciano (CH), Dipartimento di Scienze Biochimiche dell Università di Roma I and Cattedra di Patologia Clinica dell Università di Chieti, Italy
C. P. Quaratino, A. Giacomello, N. Di Sciascio & A. Colosimo
Ietituto di Chimica Biologica, University of Pisa, Pisa, Italy
M. Ranieri-Paggi, F. Ronca, P. E. Brown, A. J. G. Moir & A. Raggi
Frebs Institute. Dept. of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK
P. E. Brown & A. J. G. Moir
Institute of Biochemistry, Humboldt University, Hessische Str. 3-4, D-O-1040, Berlin, FRG
Schwendel A. & Holzhuetter H. G.
Clinic of Physiotherapy, Charitè, Schumannstr. 20-21, D-O-1040, Berlin, FRG
Grune T.
Herzog-Julius Hospital of Rheumatology and Orthopaedics, Kurhausstr.13-17, D-W-3388, Bad Harzburg, FRG
Siems W. G.
Centre for Metabolic Disorders, 1st Medical Faculty, Charles University, Prague
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Department of Pediatrics, Thomayer's Hospital, Prague
H. A. Simmonds
Purine Research Laboratory, Guy's Hospital, London
J. A. Duley
Istituto Policattedra di Discipline Biologiche, Università degli Studi di Pisa, Via Bonanno 6, 56100, Pisa, Italy
G. Senatore, G. Del Lucchese, C. Martini & A. Lucacchini
Dipartimento di Biologia Molecolare, Università di Siena, Italy
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Purine Research Laboratory, Guy's Hospital, London, UK
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Herzog Julius Hospital for Rheumatology and Orthopaedics, Kurhausstr. 13-17, W-3388, Rad Harzburg, Germany
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A. C. Skladanowski & W. Makarewicz
Departments of Pediatrics and Clinical Chemistry, Academic Medical Center Amsterdam, Meibergdreef 9, 1105, AZ Amsterdam, The Netherlands
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Institute of Cancer Research Sutton, SM2 5NG, Surrey, UK
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Purine Research Laboratory, Guy's Hospital, London, UK
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H. A. Simmonds, R. T. Smolenski, M. M. Zydowo & W. Makarewicz
Istituto di Reumatologia, Università “La Sapienza” di Roma e Cattedra di Patologia Clinica dell' Università di Chieti, Italy
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Dept. of Pediatrics, University Hospital of Antwerp and Lab. of Clinical Biochemistry, Faculty of Medicine, Antwerp, Belgium
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Additional information
This work was supported by MURST (40%)
This study was supported by a grant from theDutch Foundation for Pediatric Cancer Research S.K.K. no. 90-02.
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Agostinho, A.B., Rosi, F., Tabucchi, A. et al. Abstracts of poster presentations. Pharm World Sci 15 (Suppl 4), F15–F30 (1993). https://doi.org/10.1007/BF02297671
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DOI: https://doi.org/10.1007/BF02297671
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