Experientia

, Volume 21, Issue 5, pp 241–246 | Cite as

Un développement nouveau de la lyophilisation: La cryodessiccation des systèmes non aqueux

  • Louis Rey
Übersichtsreferate

Summary

A new development is made to enlarge the field of lyophilization using non-aqueous media. Unstable compounds are preserved by freezing and drying their solutions in organic solvents. The same technique applied to chemicals dissolved in liquid ammonia enables the preparation of stable concentrated free radicals, due to the very low temperature of sublimation of frozen NH3. Finally, experiments are made demonstrating the possibilities of high velocity, low temperature sublimation of solutions in solid CO2 at normal atmospheric pressure.

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References

  1. 1.
    Brevets Air Liquide —Rey (1964).Google Scholar
  2. 2.
    M. Dousset, Thèse de Biophysique, Université de Dijon, France (1964).Google Scholar
  3. 3.
    L. Rey,Les orientations nouvelles de la lyophilisation dansAspects théoriques et industriels de la lyophilisation (Ed.:Hermann, Paris 1964), p. 621.Google Scholar
  4. 4.
    L. Rey, Ann. N.Y. Acad. Sci.85, 510 (1960).PubMedGoogle Scholar
  5. 5.
    L. Rey,Fundamental aspects of lyophilisation dansAspects théoriques et industriels de la lyophilisation (Ed.:Hermann, Paris 1964), p. 23.Google Scholar
  6. 6.
    M. Dousset etG. Clement, Travaux des Laboratoires de Biologie Physico-Chimique et de Physiologie Générale, Faculté des Sciences de Dijon (1964), non publiés.Google Scholar

Copyright information

© Birkhäuser Verlag 1965

Authors and Affiliations

  • Louis Rey
    • 1
    • 2
  1. 1.Faculté des Sciences de DijonFrance
  2. 2.Nestlé Alimentana S.A.VeveySuisse

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