The laxative action of anthracene derivatives
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After oral administration of rhein to rats, three rhein containing fractions were isolated from the urine: rhein, rheinmonoglucuronide and rheinmonosulphate. Rheinmonoglucuronide was identified by determination of the hydroxyanthraquinone- and the glucuronic acid component and by enzymatic cleavage withΒ-glucuronidase. Rheinmonosulphate could be split by sulphatase. Within 72 h after administering rhein to rats, only 17 to 20% anthracene derivatives could be recovered from the faeces and urine.
KeywordsGlucuronic Acid Rhein Anthracene Derivative Pharmaceutisch Weekblad Scientific Edition Caecum Content
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