Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 950–956 | Cite as

The laxative action of anthracene derivatives

3. Absorption, metabolism and excretion of rhein in the rat
  • L. Lemmens
  • M. Dreessen
Article

Abstract

After oral administration of rhein to rats, three rhein containing fractions were isolated from the urine: rhein, rheinmonoglucuronide and rheinmonosulphate. Rheinmonoglucuronide was identified by determination of the hydroxyanthraquinone- and the glucuronic acid component and by enzymatic cleavage withΒ-glucuronidase. Rheinmonosulphate could be split by sulphatase. Within 72 h after administering rhein to rats, only 17 to 20% anthracene derivatives could be recovered from the faeces and urine.

Keywords

Glucuronic Acid Rhein Anthracene Derivative Pharmaceutisch Weekblad Scientific Edition Caecum Content 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adachi, S. (1965)J. Chromatogr. 17, 295–306.CrossRefPubMedGoogle Scholar
  2. Bellaart, A. G. (1952)Thesis. Groningen.Google Scholar
  3. Bremer, D. D., andA. J. Baars (1976)Pharmacology (Basle) 14, Suppl. 1, 30–47.CrossRefGoogle Scholar
  4. Dische, Z. (1947)J. Biol. Chem. 167, 189–198.PubMedGoogle Scholar
  5. Dobbs, H. E., A. C. Lane andI. R. Macfarlane (1975)Il Farmaco, Ed. Sci. 30, 147–158.Google Scholar
  6. Ippen, H. (1959)Planta Med. (Stuttgart) 7, 423–426.CrossRefGoogle Scholar
  7. Ippen, H., andT. Montag (1958)Arzneimittel-Forsch. 8, 778–779.Google Scholar
  8. Lemmens, L. (1976)Pharm. Weekblad 111, 113–118; (1979)Pharm. Weekblad Sci. Ed. 1, 2–9.Google Scholar
  9. Longo, R. (1975) Personal communication.Google Scholar
  10. Mahner, B., andH. J. Dulce (1968)Z. Klin. Chem. Klin. Biochem. 6, 99–102.PubMedGoogle Scholar
  11. Partridge, S. M. (1948)Biochem. J. 42, 238–246.CrossRefPubMedCentralGoogle Scholar
  12. Richter, G. (1966)Deut. Apotheker-Ztg. 106, 1829–1833.Google Scholar
  13. Schmid, W. (1949)Naunyn-Schmiedebergs Arch. Pharmakol. Exptl. Pathol. 208, 177–178.CrossRefGoogle Scholar

Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • L. Lemmens
    • 1
  • M. Dreessen
    • 1
  1. 1.Instituut voor Farmaceutische Wetenschappen, Laboratorium voor FarmacognosieKatholieke Universiteit te LeuvenLeuvenBelgium

Personalised recommendations