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Preparation and use ofα-bromomono- and-bromobis-difluoromethoxyacetophenones in the synthesis of polymethyleneimidazoles with an angular nitrogen atom

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The synthesis of α-bromo-4-difluoromethoxy- and α-bromo-2,4-bis(difluoromethoxy)acetophenones has been carried out. Conditions have been studied for condensing the latter with cyclic tri- and tetramethylenamidinines and with pyridine-containing derivatives. A series of pyrrolo[1,2-a]imidazole and imidazo[2,1-a]pyridine derivatives containing difluoromethoxy groups has been synthesized.

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References

  1. P. E. Bender, US Patent 4,186,205; Chem. Abs.,92, 181195 (1980).

    Google Scholar 

  2. A. Andreani, M. Rambaldi, and G. Locatelli, Eur. J. Med. Chem.,29 339 (1994).

    Google Scholar 

  3. Y. Morisawa, T. Okada, T. Okazoe, N. Nakamura, Y. Inoe, and H. Ebisu, Japanese Patent 94,184,148; Chem. Abs.,121, 300893 (1994).

    Google Scholar 

  4. G. B. Barlin, L. P. Davies, and P. W. Harrison, Austral. J. Chem.,48, 1031 (1995).

    Google Scholar 

  5. L. M. Yagupol'skii, Aromatic and Heterocyclic Compounds with Fluorine-Containing Substituents [in Russian], Naukova Dumka, Kiev (1988), p. 319.

    Google Scholar 

  6. V. V. Kastron, R. O. Vitolin', G. Ya. Dubur, I. P. Skrastin'sh, and A. A. Kimenis, Khim.-farm. Zh.,21, 554 (1987).

    Google Scholar 

  7. V. V. Kastron, R. O. Vitolin', Yu. A. Fialkov, S. V. Shelyazhenko, G. Ya. Dubur, A. A. Kimenis, and L. M. Yagupol'skii, Authors Certificate 706,410 USSR; Byull. Izobret., No. 48, 88 (1979).

    Google Scholar 

  8. Yu. A. Fialkov and S. V. Shelyazhenko, Authors Certificate 1,085,971 USSR; Byull. Izobret., No. 14, 79 (1984).

    Google Scholar 

  9. S. V. Shelyazhenko, Yu. A. Fialkov, and L. M. Yagupol'skii, Zh. Org. Khim.,28, 1652 (1992)

    Google Scholar 

  10. E. J. Moriconi and A. A. Cevasco, J. Org. Chem.,33, 2109 (1968).

    Google Scholar 

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Authors
  1. A. M. Demchenko
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  2. K. G. Nazarenko
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  3. D. V. Fedyuk
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  4. Yu. A. Fialkov
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  5. S. V. Shelyazhenko
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  6. L. M. Yagupol'skii
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Additional information

T. G. Shevchenko Chernigov Pedagogical Institute, Chernigov 250038. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 252660. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1371–1376, October, 1997.

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Demchenko, A.M., Nazarenko, K.G., Fedyuk, D.V. et al. Preparation and use ofα-bromomono- and-bromobis-difluoromethoxyacetophenones in the synthesis of polymethyleneimidazoles with an angular nitrogen atom. Chem Heterocycl Compd 33, 1191–1195 (1997). https://doi.org/10.1007/BF02290868

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  • DOI: https://doi.org/10.1007/BF02290868

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