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A comparative evaluation of separation properties for optically active dipeptide stationary phases

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Summary

Optically active dipeptide stationary phases, N-trifluoroacetyl (N-TFA)-L-isoleucyl-L-isoleucine cyclohexyl ester, N-TFA-L-norvalyl-L-norvaline cyclohexyl ester, and N-TFA-L-α-amino-n-butyryl-L-α-amino-n-butyric acid cyclohexyl ester have been synthesized. These three dipeptide derivatives have been investigated and found to surpass earlier phases with regard to the complete resolution of naturally occurring amino acids and their enantiomers. It has been further demonstrated that current methods for the evaluation of these types of phase are not adequately descriptive and the need for new criteria for quality determination of optically active stationary phases is prevalent.

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Author notes

  1. P. Y. Howard

    Present address: Varian Associates, 611 Hansen Way, 94303, Palo Alto, California, U.S.A.

Authors and Affiliations

  1. Department of Chemistry, University of Houston, 77004, Houston, Texas, U.S.A.

    P. Y. Howard & W. Parr

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  1. P. Y. Howard
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  2. W. Parr
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Howard, P.Y., Parr, W. A comparative evaluation of separation properties for optically active dipeptide stationary phases. Chromatographia 7, 283–287 (1974). https://doi.org/10.1007/BF02290544

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