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Chromatographia

, Volume 34, Issue 1–2, pp 48–50 | Cite as

Chromatographic resolution of racemic amines, carboxylic acids, and alcohols by a new homochiral reagent derived fromendo-borneol

  • M. R. Banks
  • J. I. G. Cadogan
  • I. M. Dawson
  • I. Gosney
  • K. J. Grant
  • S. Gaur
  • P. K. G. Hodgson
  • D. E. Stevenson
Originals

Summary

Chromatographic separation of racemic amines, carboxylic acids and alcohols can be achieved with excellent resolution as measured in terms of the chromatographic separation factor α by derivatization with a homochiral oxazolidin-2-one easily prepared in three steps fromendo-borneol. The resolved materials can be isolated in excellent yields by cleavage of the resultant diastereomers using conventional methods, which also allow recovery of the chiral resolving agent for re-use.

Key Words

Column liquid chromatography Diastereomer separation Chiral derivatizing agent Chiral oxazolidin-2-one 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1992

Authors and Affiliations

  • M. R. Banks
    • 1
  • J. I. G. Cadogan
    • 2
  • I. M. Dawson
    • 1
  • I. Gosney
    • 1
  • K. J. Grant
    • 1
  • S. Gaur
    • 1
  • P. K. G. Hodgson
    • 2
  • D. E. Stevenson
    • 1
  1. 1.Department of ChemistryUniversity of EdinburghEdinburghScotland
  2. 2.Sunbury Research CentreBP International Ltd.Sunbury-on-ThamesEngland

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