Summary
The preparation of graphite-layer capillary column is described together with their application to the analysis of aliphatic and aromatic amines. Attention is mainly focused on the separation of ephedrines which, being sympathomimetic amines, are often present in pharmaceutical preparations, but are also illegally used by athletes as stimulants.
Complete separation of these compounds, using direct GC-NPD analysis of human urine extract, without derivatisation, has been obtained.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
List of Doping Classes and Methods, International Olympic Committee, Lausanne, 1991.
A. Goodman Gilman, T. W. Rall, A. S. Neis, P. Taylor, The pharmacological Basis of Therapeutics, 8th edition, Zanichelli Editor, Bologna, 1992, p. 198.
M. Donike, J. Derenbach, Anal. Chem.279, 128 (1976).
F. Bruner, G. Crescentini, F. Mangani, M. Xiang, Ann. Chim.77, 745 (1987).
F. Bruner, L. Lattanzi, F. Mangani, M. Attaran Rezai, Chromatographia38, 98 (1994).
F. Bruner, P. Ciccioli, G. Crescentini, M. T. Pistolesi, Anal. Chem.45, 1851 (1973).
F. Bruner, P. Ciccioli, G. Bertoni, A. Liberti, J. Chromatogr. Sci.12, 758 (1974).
A. Di Corcia, A. Liberti, R. Samperi, Anal. Chem.45, 1228 (1973).
A. Di Corcia, Anal. Chem.45, 492 (1973).
C. G. Scott, D. A. Rowell, Nature187, 143 (1960).
I. Halász, C. Horváth, Anal. Chem.36, 69 (1973).
F. Bruner, G. Crescentini, F. Mangani, P. Palma, M. Xiang, J. Chromatogr.399, 87 (1987).
L. Lattanzi, M. Attaran Rezai, L. Sampaolo, Chromatographia40, 729 (1995).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lattanzi, L., Rezai, M.A. & Buiarelli, F. Complete separation of ephedrines by graphite-layer open-tubular (GLOT) column. Chromatographia 42, 309–312 (1996). https://doi.org/10.1007/BF02290315
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02290315