Abstract
Atypical antipsychotics account for more than 60% of antipsychotic prescriptions written for the treatment of schizophrenia. While switching from one antipsychotic to another is a dynamic process, there has been no research on individual patient and institutional characteristics that predict antipsychotic switching. VA national administrative data were used to identify patients (n=9660) with schizophrenia maintained on antipsychotic medication. Logistic regression was used to identify predictors of medication switching. Independent variables included information about service utilization, sociodemographic and clinical variables as well as institutional characteristics. This model was repeated for more specific switches between classes of medications and between specific medications. High levels of outpatient and inpatient service use were the most powerful predictors of switching. Sociodemographic, institutional, diagnostic, and functional measures were also predictive in some cases. Controlling for independent sociodemographic, diagnostic, and functional measures, frequency of clinical contact was the most robust predictor of switching antipsychotics.
References
Leslie D, Rosenheck R. The effect of institutional fiscal stress on the use of atypical antipsychotic medications in the treatment of schizophrenia.Journal of Nervous and Mental Disease. 2001;189(6):377–383.
Leslie D, Rosenheck R. From conventional antipsychotics to atypicals and back: dynamic processes in the diffusion of new medications.American Journal of Psychiatry. 2002;159(9):1534–1540.
Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association; 1994.
Rosenheck R, Stolar M. Access to public mental health services: determinants of population coverage.Medical Care. 1998;36(4):503–512.
Rosenheck R, Greenberg G, DiLella D.Department of Veterans Affairs National Mental Health Program Performance Monitoring System: Fiscal Year 2000 Report. West Haven, Conn: Northeast Program Evaluation Center; 2001.
Hwang J, Yang C, Yu H, et al. The efficacy and safety of ripseridone for the treatment of geriatric psychosis.Journal of Clinical Psychopharmacology. 2001;21(6):583–587.
Tami M, Palmer L, Russo P, et al. Schizophrenia care and assessment program: treatment by race. Presented at: the Annual Meeting of the American Psychiatric Association; May 2002; Philadelphia, Pa.
Woods S, Sullivan M, Neuse E, et al. Influence of race/ethnicity on antipsychotic prescribing practices in a community mental health center.Psychiatric Services. 2003;54(2):177–179.
Shelton R, Tollefson G, Tohen M, et al. A novel augmentation strategy for treating resistant major depression.American Journal of Psychiatry. 2001;158(1):131–134.
Food and Drug Administration. NDA 20-592/SE1-011. Available at: www.fda.gov/cder/approval/z.htm. Accessed August 3, 2003.
Valenstein M, Copeland L, Owen R, et al. Delays in adopting evidence-based dosages of conventional antipsychotics.Psychiatric Services. 2001;52(9):1242–1244.
Tapp A, Wood A, Secrest L, et al. Combination antipsychotic therapy in clinical practice.Psychiatric Services. 2003;54(1):55–59.
Author information
Authors and Affiliations
Corresponding author
Additional information
Dr Sernyak has served on an advisory board for Janssen and Lilly. He is on the speakers' bureau of Pfizer. He has received financial support for the work described in this article from AstraZeneca.
Dr Rosenheck is a consultant to Bristol Meyers Squibb and receives grant support from Janssen, Lilly, and AstraZeneca.
Rights and permissions
About this article
Cite this article
Sernyak, M.J., Leslie, D. & Rosenheck, R. Predictors of antipsychotic medication change. The Journal of Behavioral Health Services & Research 32, 85–94 (2005). https://doi.org/10.1007/BF02287330
Issue Date:
DOI: https://doi.org/10.1007/BF02287330