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Changes in microsomal lipids of rat liver after chronic carbon tetrachloride intoxication

  • Specialia
  • Chimica, Biochimica, Biophysica
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Riassunto

Un prolungato trattamento con tetracloruro di carbonio, tale da indurre una grave cirrosi epatica, determina una diminuzione degli acidi grassi più insaturi (acido arachidonico ed acido docosaexenoico) dei fosfolipidi dei microsomi di fegato di ratto. L'ipotesi che tale diminuzione sia dovuta ad una parziale distruzione di questi acidi grassi attraverso un processo di perossidazione lipidica indotto dal CCl4, è avvalorata dalla presenza, nei lipidi microsomiali, di una banda di assorbimento caratteristica dei «dieni coniugati».

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Authors and Affiliations

  1. Istituto di Patologia Generale dell'Università di Pisa, Via Roma 55, I-56100, Pisa, Italy

    M. Comporti, G. Landucci & F. Raja

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  1. M. Comporti
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  2. G. Landucci
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  3. F. Raja
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Comporti, M., Landucci, G. & Raja, F. Changes in microsomal lipids of rat liver after chronic carbon tetrachloride intoxication. Experientia 27, 1155–1156 (1971). https://doi.org/10.1007/BF02286894

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